Pathology - Male Flashcards
Abnormal opening on the ventral aspect on the penis
Hypospadias
Abnormal opening on the dorsal aspect of the penis
Epispadias
Local inflammation of the glans penis
Balanitis
Inflammation of the overlying prepuce
Balanoposthitis
prepuce cannot be retracted easily
phimosis
Penile neoplasms usually
squamous (uncircimsized) > 40y/o, can spread to inguinal lymph node (poor prognosis)
Carcinoma in situ of penis; a/w HPV - gray, crusty plaques on the penis
Bowen disease
Red velvety plaques on the penis a/w HPV
Erythroplasia of Queyrat
small flesh colored patches on the penis, pre-malignant (2-3%), many regress
Bowenoid Papulosis
most common cause of scrotal enlargement (serous fluid w/in the tunica vaginalis)-> transluminesence
hydrocele
Failure of testicular descent
Cryptorchidism
Post-pubertal male tumors?
germ cells 95% (all malignant)
mutation in germ cell tumors in males?
i(12p)
Female analogy to seminoma
Ovarian dysgerminoma
Large cells, distinct border, rare lymphocytes
seminoma
Older pt, no a/w intratubular germ cell neoplasia, polygonal cells of variable size organized in nodules/ sheets
spermatocyte seminoma
most common testicular neoplasm in young boys, good prognosis; a/w embryonic cacrinoma in adults
yolk sac tumor
buzz pathology word for yolk sac tumor
Schiller-Duvall bodies
tumor markers (2) for yolk sac
anti-trypsin &AFP
indistinct boder, ill-defined, hemorrhage & necrosis testicular carcinoma
embyronic carcinoma
testicular carcinoma - pleuripotent; diff. along trophoblastic lines; increase in HCG, poor prognsosis
hemorrhage & necrosis
choriocarcinoma
neoplastic germ cells diff. along somatic lines (mostly in combo w/ other cell types)
(pre-puberty = benign)
(post-puberty = malignant)
Teratoma
tx for bacterial prostitis
Trimethoprim/sulfa or cipro (Rx delivery)
Cause of granulomatous prostitis due to?
BCG instillation in bladder for tx of superficial bladder cx
Benign Prostate Hyperplasia (BPH)
stromal & epithelial elements, excessive androgen (DHT) growth; hyperplastic gland
BPH, hyperplastic glands, inner columnar, outer flat squamous, secrete proteinaceous…
corpora amylacea
RX that blocks DHT formation
Finestride
Rx that blocks adrenergic receptors for BPH
Flomax
Prostate cx is graded by?
Gleason system
pouch-like evagination mostly due to urethral obstruction
bladder diverticulum
Can result in transmural fibrosis –> painful contracted bladder
Intersitial cystitis
phagosomes become overloaded, enlarged lysosomes
Malakoplakia - Michaelis Gutmann bodies
Bladder cx presentation
painless hematuria
A/w squamous bladder cx
urinary Schistomiasis
tertial syphilis, necrotic tissue in bone, skin, mucous membranes, upper airway
gumma
Congential Syphilis, Huthison Triad
1- notched incisors
2- intersitial keratitis w/ blindness
3- deafness (8th CN)
Chronic ulcerative disease caused by Chylamdia, mixed granulomatous, neutrophilic inflammatory response
Steleate abscesses in lymph nodes increase lymphedema
LGV= lymphogranuolma venereum
Most common cause of ulcers in Africa & Asia/ painful; Haemophilius
Chancroid
Protozoa that may increase pH by decreasing acid producing Duderlein bacili
Trichomonas
Neonatal HSV fatal b/c a/w
rash, encephilits, pneumonitis, hepatic necrosis
HPV complications in neonate
papillomas in upper respiratory tract
Another name for yolk sac tumor
Endodermal sinus
Nearly always malignant in men and equivalent of a dermatoid cyst in women is nearly always benign
Mature teratoma
non-germ cell tumor from testicular stroma; intracytoplasmic Reinke crystals
can cause precocious puberty in children or gynecomastia in adults
Leydig tumor
Increase in free PSA a/w?
BPH
Increase in bound alpha-antichymotrypsin
prostate cx
Donovan bodies a/w?
Granuloma inguinale Calymmatobacterium granulomatis (gram neg rod)