Teratogenic meds

Question 1

Phenytoin

Answer 1

1. Neural tube
2. Microcephaly
3. Orofacial celfts
4. dysmorphic facial features
5. Digit/nail hypoplasia

Question 2

Lithium

Answer 2

1. Ebstein anomaly
2. Nephrogenic DI
3. Hypothyroidism

Question 3

Valproate

Answer 3

1. Neural tube defects (meningocele/meningomyelocele)

Question 4

Isotretinoin

Answer 4

1. Microcephaly
2. Thymic hypoplasia
3. Small ears
4. Hydrocephalus

Question 5

Methotrexate

Answer 5

1. Limb and craniofacial abnormalities
2. Neural tube defects
3. Abortion

Question 6

ACE inhibitors

Answer 6

1. Renal dysgenesis

2. Oligohydramnios

Question 7

Warfarin

Answer 7

1. Nasal hypoplasia

2. Stippled epiphysis