Teratogen Flashcards

1
Q

Preimplantation period

A

2 weeks from in fertilization to implatation

All or none period

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2
Q

Embryonic period

A

2nd to 8th week

Organogenesis

Most crucial to structural malformation

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3
Q

Alteration in cardiac blood flow can result in what deformation during the fetal period

A

Hypoplastic left heart

Aortic coarctation

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4
Q

Category A

A

Pregnant women have not shown an increased risk for fetal abnormalities

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5
Q

Example of category A

A

Levothyroxine
Potassium supp
Prenatal multivitamin

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6
Q

Define category B

A

Animal rep studies have been performed and revealed no harm to the fetus

Animal studies have shown an AE but adequate and well controlled studies have failed to demonstrate

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7
Q

Examples of category b

A

Penicillins
Macrolides
Cephalosporin

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8
Q

Define category C

A

No adequate and well studies in pregnant women but a teratogenic

No animal reproduction and no adequate

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9
Q

Examples of category C

A
Albutero
Zidovudine
Lamivudine
Beta blockers
Calcium channel blockers
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10
Q

Example of category D

A
Systemic corticosteroids
Azathioprine
Phenytoin
Carbamazepine
Valproic acid
Lithium
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11
Q

Disruption of Folic Acid metab can cause

A

NTD
Cardiac defects
Cleft lip and palate

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12
Q

What are the drugs that can affect FA metab

A

Hydantoin
Carbamazepine
Valproic acid
Phenobarbital

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13
Q

What can cause teratogenic to the paternal

A

Ethyl alcohol
Cyclophosphamide
Lead
Opiates

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14
Q

Considered epileptic DOC for pregnancy

A

Carbamazepine

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15
Q

Side effects of ACEi

-pril

A

Prolonged fetal ftn

Renal hypoperfusion

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16
Q

What antifungal canncause ANTLEY BIXLER SYNDROME

A

Fluconazole

17
Q

What NSAIDS are considered reversible during 3rd trimester

And can cause pulmonary htn

A

Ibuprofen

Indomethacin

18
Q

This drug is pyrimidine synthesis inhibitor but CI to pregnancy

A

Leflunomide

19
Q

Causes discoloration of diciduous teeth

A

Tetracycline
Doxycycline
Minocycline

20
Q

Causes nephrotoxicity and ototoxicty in pre term infants

A

Aminoglycosides

Streptomycin
Gentamicin

21
Q

What antineoplastic agent can cause skeletal and limb defect during first trimester

A

Cyclophosphamide

22
Q

What androgen progestin can cause virilization of female fetus with slight cardiac defect

23
Q

This is a carcinogen and teratogen at the same time

A

Diethylstilbestrol

24
Q

Does not represent a major teratogenic risk

A

Corticosteroids

Glucocorticoid
Mineralocorticoid

25
Can cause developmental delay and mild neurological abnormalities such a microcephaly and severe brain damage
Mercury
26
Not a teratogenic but can cause VSD
SSRI SNRI Except paroxetine
27
What anti psychotic medications are allowed
``` Haloperidol Chlorpromazine Aripipazole Olanzapine Quetiapine Risperidone ```
28
Used to treat severe psoriasis replacing etretinate Atleast 3 years
Acitretin
29
Used to treat acne and sun damage
Tretinoin | Tazarotene
30
What can cause phocomelia
Thalidomide
31
Treatment for obesity, narcolepsy and ADD FGR and with behavioral abnormalities
Amphetamines
32
Maternal complication of cocaine
Cerebrovascular hemorrhage Myocardial damage Placental abruption