Teratogen

Question 1

Preimplantation period

Answer 1

2 weeks from in fertilization to implatation

All or none period

Question 2

Embryonic period

Answer 2

2nd to 8th week

Organogenesis

Most crucial to structural malformation

Question 3

Alteration in cardiac blood flow can result in what deformation during the fetal period

Answer 3

Hypoplastic left heart

Aortic coarctation

Question 4

Category A

Answer 4

Pregnant women have not shown an increased risk for fetal abnormalities

Question 5

Example of category A

Answer 5

Levothyroxine
Potassium supp
Prenatal multivitamin

Question 6

Define category B

Answer 6

Animal rep studies have been performed and revealed no harm to the fetus

Animal studies have shown an AE but adequate and well controlled studies have failed to demonstrate

Question 7

Examples of category b

Answer 7

Penicillins
Macrolides
Cephalosporin

Question 8

Define category C

Answer 8

No adequate and well studies in pregnant women but a teratogenic

No animal reproduction and no adequate

Question 9

Examples of category C

Answer 9

Albutero
Zidovudine
Lamivudine
Beta blockers
Calcium channel blockers

Question 10

Example of category D

Answer 10

Systemic corticosteroids
Azathioprine
Phenytoin
Carbamazepine
Valproic acid
Lithium

Question 11

Disruption of Folic Acid metab can cause

Answer 11

NTD
Cardiac defects
Cleft lip and palate

Question 12

What are the drugs that can affect FA metab

Answer 12

Hydantoin
Carbamazepine
Valproic acid
Phenobarbital

Question 13

What can cause teratogenic to the paternal

Answer 13

Ethyl alcohol
Cyclophosphamide
Lead
Opiates

Question 14

Considered epileptic DOC for pregnancy

Answer 14

Carbamazepine

Question 15

Side effects of ACEi

-pril

Answer 15

Prolonged fetal ftn

Renal hypoperfusion

Question 16

What antifungal canncause ANTLEY BIXLER SYNDROME

Answer 16

Fluconazole

Question 17

What NSAIDS are considered reversible during 3rd trimester

And can cause pulmonary htn

Answer 17

Ibuprofen

Indomethacin

Question 18

This drug is pyrimidine synthesis inhibitor but CI to pregnancy

Answer 18

Leflunomide

Question 19

Causes discoloration of diciduous teeth

Answer 19

Tetracycline
Doxycycline
Minocycline

Question 20

Causes nephrotoxicity and ototoxicty in pre term infants

Answer 20

Aminoglycosides

Streptomycin
Gentamicin

Question 21

What antineoplastic agent can cause skeletal and limb defect during first trimester

Answer 21

Cyclophosphamide

Question 22

What androgen progestin can cause virilization of female fetus with slight cardiac defect

Answer 22

MPAt

Question 23

This is a carcinogen and teratogen at the same time

Answer 23

Diethylstilbestrol

Question 24

Does not represent a major teratogenic risk

Answer 24

Corticosteroids

Glucocorticoid
Mineralocorticoid

Question 25

Can cause developmental delay and mild neurological abnormalities such a microcephaly and severe brain damage

Answer 25

Mercury

Question 26

Not a teratogenic but can cause VSD

Answer 26

SSRI
SNRI

Except paroxetine

Question 27

What anti psychotic medications are allowed

Answer 27

Haloperidol
Chlorpromazine
Aripipazole
Olanzapine
Quetiapine
Risperidone

Question 28

Used to treat severe psoriasis replacing etretinate

Atleast 3 years

Answer 28

Acitretin

Question 29

Used to treat acne and sun damage

Answer 29

Tretinoin

Tazarotene

Question 30

What can cause phocomelia

Answer 30

Thalidomide

Question 31

Treatment for obesity, narcolepsy and ADD

FGR and with behavioral abnormalities

Answer 31

Amphetamines

Question 32

Maternal complication of cocaine

Answer 32

Cerebrovascular hemorrhage
Myocardial damage
Placental abruption