Tenecteplase Flashcards
1
Q
Pharmacology of Tenecteplase
A
It is a fibrinolytic
2
Q
What is the pharmacology of Tenecteplase
A
It is a thrombolytic agent which converts thrombus bound plasminogen to plasmin. this degrades the fibrin matrix of the thrombus, degrading the clot.
3
Q
What indications does tenecteplase have?
A
Patients with a stemi who meet the criteria for pre-hospital tenecteplase.
4
Q
What contraindications does tenecteplase have?
A
<18 years or >75 years Uncontrolled hypertension (>180 and or a diastolic above 110mmHg at any stage during ACS) Allergy/ADR LBBB Active Tuberculosis Current or history of thrombocytopenia Prior intracranial haemorrhage suspected aortic dissection pregnancy or 2/52 post partum AAMI from trauma prolonged CPR Bleeding or clotting disorder (many, many more)
5
Q
Precautions of tenecteplase
A
Nil
6
Q
Side effects of tenecteplase
A
Haemorrhage
Post-administration dysrhythmias
7
Q
Route of administration for tenecteplase
A
IV
8
Q
Presentation of Tenecteplase
A
Injection > 50mg (10,000 IU)
9
Q
Onset, duration and half life of tenecteplase
A
15 minutes, several hours, 2 hours
10
Q
Dosage of Tenecteplase
A
Weight Based
70-80 KG 40mg
80-90 KH 45mg
90 > 50mg
