Tema 2 Flashcards

1
Q

Intracellular

A
Innata: 
NK, macrófagos
Activacion de complement
Adquirida: 
Th1 -> mayor activación de macrófagos
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2
Q

Extracellular

A
Innata: 
Neutrófilos, macrófagos, eosinófilos
Activacion de coplement
Adquirida: 
Th2 -> antibodies ( neutralización, opsonización y fagocitosis)
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3
Q

Inicia de la respuesta

Células infectadas producen :

A

IFN a
IFN b
IFN y
IFN-lamda

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4
Q

IFNa

A

Inhibe la replicación viral
- no se forme el virión (bloquea traducción ARN. virico)
Promueve la muerte de la célula vía BCL-2(regulate apoptosis) o caspasas
Enhances proliferation of B cells
Activate NK and CD
Activated CD promote Th1 response
Increased MHC II expression

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5
Q

NK activados secretan

A

IFN y
- Activan APC -> Th1 -> CTL
Macrófagos y CPA expresa HLA-I (TAP) -> activación de TCD8
Macrófagos síntetisise NO

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6
Q

INF-1

A

a y b

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7
Q

INF-2

A

y

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8
Q

INF-3

A

lamda

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9
Q

Macrófago

A
Produce IFNa
-> muerte celular
->reclutamiento de leucocitos
-> fiebre
IL12, 15, 18
-> activa NK, Th1
Degradación de los virus (proteasas, ROS, NRS)
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10
Q

Inmunidad adaptativa

diferenciación a Th1

A

CPA -> INF y IL2

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11
Q

Los principales mediadores de la respuesta innata celular frente a los virus

A

NK

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12
Q

MIC

A

Producida por unos virus

Activan los NK a través NKG2D

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