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Y6 - Acute Care and Trauma > TCA poisoning > Flashcards

TCA poisoning Flashcards

1
Q

What is the aetiology of TCA overdose?

A

Tricyclic antidepressants have a narrow therapeutic index and therefore become potent cardiovascular and central nervous system toxins in moderate doses.

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2
Q

What are signs and symptoms of TCA overdose?

A
  • Change in mental status
  • Tachycardia
  • Hypotension
  • Mydriasis
  • Warm, dry, flushed skin
  • Decreased or absent bowel sounds
  • Urinary retention
  • Ophthalmic signs
  • Neurological signs
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3
Q

What are investigations for TCA overdose?

A

ECG
Sodium bicarbonate therapeutic trial
ABG
Serum TCA concentrations

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4
Q

What is the management for TCA overdose?

A

Supportive care and management
Activated charcoal
If QRS >100ms - sodium bicarb
IV fluids
Consider gastric lavage

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5
Q

What are the complications associated with TCA overdose?

A
  • Cardiac arrhythmias
  • Delirium
  • Seizure
  • Coma
  • Cardiac arrest
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Y6 - Acute Care and Trauma (14 decks)

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