TCA cycle Flashcards

1
Q

Net energy production of TCA

A

3 NADH, 1 FADH, 1 GTP

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2
Q

What enzye in glycolysis needs NAD+ which is supplied by the conversion of pyruvate ti lactate

A

glyceraldehyde 3 phosphate dehydrogenase

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3
Q

order of prduction of high energy intermediates

A

NADh, NADH, GTP, FADH2, ___, NADH

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4
Q

what inhibits citrate synthase

A

NADH, Citrate, ATP and Succinyl coA

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5
Q

what activates citrate synthase

A

ADP

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6
Q

IMPORTANT: isocitrate dehydrogenase is inhibited by what

A

NADH and ATP

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7
Q

Isocitrate dehydrogenate is activated by

A

ADP and NAD

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8
Q

alpha KG dehydrogenase uses what co enzymes

A

TPP, lipoic acid, FAD NADH and CoA

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9
Q

What activates alpha KG dehydrgenase

A

Ca2+ and ADP

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10
Q

what inhibits alpha KG dehydrogenase

A

succinyl coA NADH GTP and ATP

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11
Q

what is the obligatory aerobic step

A

succinate dehydrogenase since you have the maintain the FAD in its oxidiaxed form

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12
Q

what is made during the succinate dehydrogenase step?

A

FADH2

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13
Q

what is fumarase important for?

A

it is a tumor supressor gene

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