TCA cycle Flashcards
Net energy production of TCA
3 NADH, 1 FADH, 1 GTP
What enzye in glycolysis needs NAD+ which is supplied by the conversion of pyruvate ti lactate
glyceraldehyde 3 phosphate dehydrogenase
order of prduction of high energy intermediates
NADh, NADH, GTP, FADH2, ___, NADH
what inhibits citrate synthase
NADH, Citrate, ATP and Succinyl coA
what activates citrate synthase
ADP
IMPORTANT: isocitrate dehydrogenase is inhibited by what
NADH and ATP
Isocitrate dehydrogenate is activated by
ADP and NAD
alpha KG dehydrogenase uses what co enzymes
TPP, lipoic acid, FAD NADH and CoA
What activates alpha KG dehydrgenase
Ca2+ and ADP
what inhibits alpha KG dehydrogenase
succinyl coA NADH GTP and ATP
what is the obligatory aerobic step
succinate dehydrogenase since you have the maintain the FAD in its oxidiaxed form
what is made during the succinate dehydrogenase step?
FADH2
what is fumarase important for?
it is a tumor supressor gene