Other AA metabolism Flashcards
aspartic acid enters TCA through
OAA
pyruvate enters TCA via
OAA
phenylalanine and tyrosine enter TCA through
fumarate
oxaloacetate is used to make energy by
going into glycolysis
glutamic acid enters the TCA through
alpha KG
glutamine enters the TCA via
alpha KG
acetoacetate cannot be used for
glucosse synthesis
how do carbon skeletons get recycled into energy
they enter the TCA cycle at various points and funnel into malate. Mlate is converted to pyruvate using malic enzyme and pyruvate become alanine. Alanine goes to the liver for gluconeogenesis
how does malate become pyruvate
through malic enzyme
What two AA can we convert arginne/ornithine to?
proline and glutamic acid
how can I make proline?
through arginine
what three things can i make from arginine?
NO, (OAA –> peutricine) and creatinine.
why is peutracine important?
assist in stabalization and replication
what enzyme goes from ornithine to petrucine
ornithine decarboxylase
what blocks ornithine decarboxylase
eflouricine
how do we produce serine?
from G3P (diversion from glycolysis)
How do we make glycine?
from serine (from G3P)
how do you go from serine to glycine? emzyme and what cofactor?
using serine hydroxymethyl transferase? You must use THF which is converted into N5N10 THF
deficiency in glycine cleavage complex
increae in glycine, which is small and an inhibitory neurotransmitter –> neurological effects
what inhibits glycine cleavage complex?
proprionic co A
histidine forms
FIGLU
what AA can be used as a source of 1C metabolism?
Serine Glycine Histidine Tryptophan
if no folate, what in the breakdown of hisitine will build up?
FIGLU
what is the molecule of the folate trap?
methyl THF will trap the folate unless you have B12
