Other AA metabolism

Question 1

aspartic acid enters TCA through

Answer 1

OAA

Question 2

pyruvate enters TCA via

Answer 2

OAA

Question 3

phenylalanine and tyrosine enter TCA through

Answer 3

fumarate

Question 4

oxaloacetate is used to make energy by

Answer 4

going into glycolysis

Question 5

glutamic acid enters the TCA through

Answer 5

alpha KG

Question 6

glutamine enters the TCA via

Answer 6

alpha KG

Question 7

acetoacetate cannot be used for

Answer 7

glucosse synthesis

Question 8

how do carbon skeletons get recycled into energy

Answer 8

they enter the TCA cycle at various points and funnel into malate. Mlate is converted to pyruvate using malic enzyme and pyruvate become alanine. Alanine goes to the liver for gluconeogenesis

Question 9

how does malate become pyruvate

Answer 9

through malic enzyme

Question 10

What two AA can we convert arginne/ornithine to?

Answer 10

proline and glutamic acid

Question 11

how can I make proline?

Answer 11

through arginine

Question 12

what three things can i make from arginine?

Answer 12

NO, (OAA –> peutricine) and creatinine.

Question 13

why is peutracine important?

Answer 13

assist in stabalization and replication

Question 14

what enzyme goes from ornithine to petrucine

Answer 14

ornithine decarboxylase

Question 15

what blocks ornithine decarboxylase

Answer 15

eflouricine

Question 16

how do we produce serine?

Answer 16

from G3P (diversion from glycolysis)

Question 17

How do we make glycine?

Answer 17

from serine (from G3P)

Question 18

how do you go from serine to glycine? emzyme and what cofactor?

Answer 18

using serine hydroxymethyl transferase? You must use THF which is converted into N5N10 THF

Question 19

deficiency in glycine cleavage complex

Answer 19

increae in glycine, which is small and an inhibitory neurotransmitter –> neurological effects

Question 20

what inhibits glycine cleavage complex?

Answer 20

proprionic co A

Question 21

histidine forms

Answer 21

FIGLU

Question 22

what AA can be used as a source of 1C metabolism?

Answer 22

Serine Glycine Histidine Tryptophan

Question 23

if no folate, what in the breakdown of hisitine will build up?

Answer 23

FIGLU

Question 24

what is the molecule of the folate trap?

Answer 24

methyl THF will trap the folate unless you have B12

Question 25

B12 defiiency leads to

Answer 25

macrocytic anemia

Question 26

only 2 rxns that use vitamin B12

Answer 26

1) making succinyl coA from propionyl coA: methylmalonyl mutase enzyme
2) converting homocysteine to methionine