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BIOCHIMIE METABO > TCA CYCLE > Flashcards

TCA CYCLE Flashcards

1
Q

TCA CYCLE est une voie

A

amphibole (catabolique et anabolique ) , oxydative ,aerobique du groupement acetyl coa

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2
Q

reaction irreversible importante formant l acetyl coa a partir le pyruvate

A

pyruvate +COASH + NAD+ ➔ Acetyl COA + CO2 + NADH,H+

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3
Q

l enzyme de la reaction importante

A

pyruvate dehydrogenese complexe

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4
Q

pyruvate dehydrogenese complexe cpntient 3 enzymes

A

. pyruvate dehydrogenase
. dihydrolipoyl transacetylase
. dihydrolipoyl deshydrogenase

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5
Q

pyruvate deshydrogenese complexe contient a 5 cofacteurs

A

. thiamine pyrophosphate
. HSCoA
.Acide lipoique
.NAD+
.FAD

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6
Q

reaction 1 irreversible et limitante

A

Acetyl CoA +H20+ OXALOACETATE ➔citrate

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7
Q

enzyme de la 1e

A

citarte synthase

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8
Q

coenzyme de la 1e

A

CoA

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9
Q

REACTION 2 reversible

A

citrate ➔ Cis aconitate ➔isocitarte

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10
Q

enzyme de la 2e

A

aconitase

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11
Q

reaction 3 irreversible et limitante

A

isocetrate ➔alpha-ketogluturate +co2

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12
Q

enzyme de la 3e

A

isocitrate deshydrogenase

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13
Q

coenzyme de la 3e

A

NAD+

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14
Q

reaction 4 irreversible et limitante

A

alpha-ketogluturate ➔succinyl Coa +co2

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15
Q

enzyme de la reaction 4

A

alpha ketoglutarate deshydrogenase

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16
Q

coenzyme de la 4e

17
Q

Reaction 5 REVERSIBLE

A

succinul CoA ➔ Succinate

18
Q

enzyme de la 5e

A

succinyl CoA synthetase

19
Q

reaction 6 reversible

A

succinate ➔fumarate

20
Q

enzyme de 6e

A

succinate deshydrogenase fixe sur la membrane interne du mito

21
Q

coenzyme de 6e

22
Q

REACTION 7 reversible

A

fumarate ➔L-malate

23
Q

enzyme de 7 e

24
Q

reaction 8 reversible

A

L-malate ➔ oxaloacetate

25
Q

enzyme de 8 e

A

malate deshydrogenase

26
Q

coenzyme de 8e

27
Q

tous les reactions produisent de l energie directement

A

non ; 4 des 8 reactions l energie est conservee dans des coenzymes
et une seule reaction produit ATP directement

28
Q

bilan

A

3NADH,H+
1 FADH2
1 ATP
=
12 ATP par 1 tour de cycle

29
Q

activateur du pyruvate deshydrogenase complexe

A

AMP , CoA , NAD+, ca2+

30
Q

inhibiteur du pyruvate deshydrogenase complexe

A

ATP , acetyl coA , NADH , FATTY acide

31
Q

activateur du citrate synthase

32
Q

inhibiteur du citrate synthase

A

NADH , CITRATE , ATP , acetyl coA

33
Q

activateur de l isocitrate deshydrogenase

A

ca2+ , ADP

34
Q

inhibiteur de l isocitrate deshydrogenase

35
Q

activateur alpha -ketogflutarate deshydrogenase

36
Q

inhibiteur de alpha ketoglutarate deshydrogenase

A

succinyl coA , NADH

BIOCHIMIE METABO (6 decks)

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