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glycolyse Flashcards

1
Q

La glycolyse se déroule au niveau

A

Cytosol

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2
Q

reactions de glycolyse

A

10

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3
Q

1ere reaction

A

D glycose ➔ D glycose 6p

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4
Q

enzyme de la 1ere reaction

A

hexokinase glucokinase

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5
Q

hexokinase

A

ubiquiste , non specifique du glycose ,affinite forte , tjrs active

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6
Q

glucokinase

A

hepatique et musculaire , specifique du glycose ,faible affinite , active ghir mora lmakla (periode post -prandial)

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7
Q

coenzyme de la 1ere reaction

A

ATP

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8
Q

cofacteur de la 1ere reaction

A

mg2+

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9
Q

la 1ere reaction est

A

IRREVERSIBLE, EXERGONIQUE

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10
Q

2eme reaction

A

D glucose 6p ➔D fructose 6p

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11
Q

2eme reaction est

A

REVERSIBLE

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12
Q

enzyme de la 2eme reaction

A

phosphoglucose isomerase

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13
Q

ccofacteur de la 2eme reaction

A

mg2+

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14
Q

3eme reaction

A

D fructose 6p ➔D fructose 1,6BP

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15
Q

3eme reaction est

A

spontanee , irreversible , exergonique
etape la plus lente
reaction limitante
etape MAJEUR de la regulation de la glycolyse

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16
Q

enzyme de la 3eme reaction

A

pfk1 (phosphofructokinase1)

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17
Q

pfk1

A

enzyme CLE de la glycolyse

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18
Q

coenzyme de la 3eme reaction

A

ATP

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19
Q

cofacteur de la 3eme reaction

A

mg2+

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20
Q

4eme reaction

A

D fructose 1,6BP ➔ dihydroxyacetone phosphate + glyceraldehyde 3P ‘ 2triose phosphate (isomeres )’

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21
Q

4e reaction est

A

reversible

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22
Q

enzyme de la 4e

A

aldolase

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23
Q

coenzyme et cofacteurs de la 4e et la 5e et de la 8e

A

makayninch :)

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24
Q

5e reaction

A

dihydroxyacetone p ➔glyceraldehyde 3p

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25
5e reaction est
reversible
26
enzyme de la 5e
triose phosphate isomerase
27
6e reaction
glyceraldehyde 3p ➔1,3 biphosphoglycerate
28
6e reaction est
reversible
29
enzyme de la 6e
glyceraldehyde 3 phosphate deshydrogenase
30
mecanisme reactionel de la 6e reaction est
couplant : oxydoreduction + transfert de phosphate
31
coenzyme de la 6e
NAD+
32
7e reaction
1,3 biphosphoglycerate ➔ 3 phosphoglycerate
33
7e reaction est
reversible, ELLE PRODUIT DE L'ATP
34
enzyme de la 7e
phosphoglycerate kinase
35
coenzyme de la 7e
ADP
36
cofacteur de la 7e
mg2+
37
8e reaction
3phosphoglycerate ➔ 2 phosphoglycerate
38
8e reaction est
reversible
39
enzyme de la 8e
phosphoglycerate mutase
40
9 reaction
2 phosphoglycearte ➔ phosphoenolpyryvate
41
9e reaction
reversible , c est une reaction de deshydratation ( sortie de H2O)
42
enzyme de la 9e
enolase
43
cofacteur de la 9e
mg2+
44
10 e reaction
phosphoenolpyruvate ➔ pyruvate
45
enzyme de la 10 e
pyruvate kinase, enzyme cle de la glycolyse
46
10e reaction
irreversible et exergonique ELLE PRODUIT DE LATP
47
coenzyme de la 10 e
ADP
48
cofacteur de la 10e
mg2+ , k+
49
bilan de la glycolyse
1 glucose + 2ADP + 2 PI + 2 NAD+ ➔2 PYRUVATE +2ATP +2 NADH,H+ 2H2O
50
GLYCOLYSE EN +O2
8ATP
51
GLYCOLYSE EN -O2
2ATP
52
pyruvate en +O2
cycle de krebs
53
pyruvate -O2
LACTATE
54
devenir NADH,H+
rentre dans le mitochondrie (CHIANE RESPIRATOIRE 3ATP)
55
2 types de regulation de la glycolyse
allosterique et hormonale
56
activateur hormonal
insulin ➔ more glycolyse (hyoglycemie )
57
inhibiteur hormonal
glucagon ➔ less glycolyse (hyperglycemie )
58
regulation de l hexokinase
activateur : glucose inhibiteur : glucose 6P
59
regulation de la pfk1
. activateur : ➔fructose 2,6 BP ➔insulin (active ma pfk2 qui produit fRUCTOSE 2,6BP ) . inhibiteur : ➔ATP ➔ glucagon ( desactive la pfk2)
60
regulation du pyruvate kinase
activateur : fructose 16BP , insuline inhibiteur : acetyl coa , ATP ,alanine , citrate , glucagon

BIOCHIMIE METABO (6 decks)

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