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BIOCHIMIE METABO > glycolyse > Flashcards

glycolyse Flashcards

1
Q

La glycolyse se déroule au niveau

A

Cytosol

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2
Q

reactions de glycolyse

A

10

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3
Q

1ere reaction

A

D glycose ➔ D glycose 6p

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4
Q

enzyme de la 1ere reaction

A

hexokinase glucokinase

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5
Q

hexokinase

A

ubiquiste , non specifique du glycose ,affinite forte , tjrs active

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6
Q

glucokinase

A

hepatique et musculaire , specifique du glycose ,faible affinite , active ghir mora lmakla (periode post -prandial)

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7
Q

coenzyme de la 1ere reaction

A

ATP

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8
Q

cofacteur de la 1ere reaction

A

mg2+

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9
Q

la 1ere reaction est

A

IRREVERSIBLE, EXERGONIQUE

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10
Q

2eme reaction

A

D glucose 6p ➔D fructose 6p

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11
Q

2eme reaction est

A

REVERSIBLE

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12
Q

enzyme de la 2eme reaction

A

phosphoglucose isomerase

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13
Q

ccofacteur de la 2eme reaction

A

mg2+

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14
Q

3eme reaction

A

D fructose 6p ➔D fructose 1,6BP

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15
Q

3eme reaction est

A

spontanee , irreversible , exergonique
etape la plus lente
reaction limitante
etape MAJEUR de la regulation de la glycolyse

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16
Q

enzyme de la 3eme reaction

A

pfk1 (phosphofructokinase1)

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17
Q

pfk1

A

enzyme CLE de la glycolyse

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18
Q

coenzyme de la 3eme reaction

A

ATP

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19
Q

cofacteur de la 3eme reaction

A

mg2+

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20
Q

4eme reaction

A

D fructose 1,6BP ➔ dihydroxyacetone phosphate + glyceraldehyde 3P ‘ 2triose phosphate (isomeres )’

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21
Q

4e reaction est

A

reversible

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22
Q

enzyme de la 4e

A

aldolase

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23
Q

coenzyme et cofacteurs de la 4e et la 5e et de la 8e

A

makayninch :)

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24
Q

5e reaction

A

dihydroxyacetone p ➔glyceraldehyde 3p

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25
Q

5e reaction est

A

reversible

26
Q

enzyme de la 5e

A

triose phosphate isomerase

27
Q

6e reaction

A

glyceraldehyde 3p ➔1,3 biphosphoglycerate

28
Q

6e reaction est

A

reversible

29
Q

enzyme de la 6e

A

glyceraldehyde 3 phosphate deshydrogenase

30
Q

mecanisme reactionel de la 6e reaction est

A

couplant : oxydoreduction + transfert de phosphate

31
Q

coenzyme de la 6e

A

NAD+

32
Q

7e reaction

A

1,3 biphosphoglycerate ➔ 3 phosphoglycerate

33
Q

7e reaction est

A

reversible, ELLE PRODUIT DE L’ATP

34
Q

enzyme de la 7e

A

phosphoglycerate kinase

35
Q

coenzyme de la 7e

A

ADP

36
Q

cofacteur de la 7e

A

mg2+

37
Q

8e reaction

A

3phosphoglycerate ➔ 2 phosphoglycerate

38
Q

8e reaction est

A

reversible

39
Q

enzyme de la 8e

A

phosphoglycerate mutase

40
Q

9 reaction

A

2 phosphoglycearte ➔ phosphoenolpyryvate

41
Q

9e reaction

A

reversible , c est une reaction de deshydratation ( sortie de H2O)

42
Q

enzyme de la 9e

A

enolase

43
Q

cofacteur de la 9e

A

mg2+

44
Q

10 e reaction

A

phosphoenolpyruvate ➔ pyruvate

45
Q

enzyme de la 10 e

A

pyruvate kinase, enzyme cle de la glycolyse

46
Q

10e reaction

A

irreversible et exergonique ELLE PRODUIT DE LATP

47
Q

coenzyme de la 10 e

A

ADP

48
Q

cofacteur de la 10e

A

mg2+ , k+

49
Q

bilan de la glycolyse

A

1 glucose + 2ADP + 2 PI + 2 NAD+ ➔2 PYRUVATE +2ATP +2 NADH,H+ 2H2O

50
Q

GLYCOLYSE EN +O2

A

8ATP

51
Q

GLYCOLYSE EN -O2

A

2ATP

52
Q

pyruvate en +O2

A

cycle de krebs

53
Q

pyruvate -O2

A

LACTATE

54
Q

devenir NADH,H+

A

rentre dans le mitochondrie (CHIANE RESPIRATOIRE 3ATP)

55
Q

2 types de regulation de la glycolyse

A

allosterique et hormonale

56
Q

activateur hormonal

A

insulin ➔ more glycolyse
(hyoglycemie )

57
Q

inhibiteur hormonal

A

glucagon ➔ less glycolyse
(hyperglycemie )

58
Q

regulation de l hexokinase

A

activateur : glucose
inhibiteur : glucose 6P

59
Q

regulation de la pfk1

A

. activateur : ➔fructose 2,6 BP
➔insulin (active ma pfk2 qui produit fRUCTOSE 2,6BP )
. inhibiteur : ➔ATP
➔ glucagon ( desactive la pfk2)

60
Q

regulation du pyruvate kinase

A

activateur : fructose 16BP , insuline
inhibiteur : acetyl coa , ATP ,alanine , citrate , glucagon

BIOCHIMIE METABO (6 decks)

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