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BIOCHIMIE METABO > ppp > Flashcards

ppp Flashcards

1
Q

ppp se deroule

A

cytosol des glandes mammaires , des tissus adipeux , foie , rein

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2
Q

ppp est

A

ubiquiste et voie anabolique

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3
Q

substrat de ppp

A

glucose 6p

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4
Q

ppp represente

A

8 reactions : 2 phases

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5
Q

phases de ppp

A

1) oxydative et irreversible ( reaction 1 2 3 )
2) non oxydative et reversible ( 3a , 3b , 4 , 5, 6 )

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6
Q

PHASE 1 produit

A

2NADPH ,H+ , ribulose P

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7
Q

PHASE 2 produit

A

ribose 5P

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8
Q

role du NADPH

A

synthese des acides gras , cholesterol , hormone streoides

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9
Q

role du ribose 5P

A

synthese du nucleotides , coenzyme (NADH,H+ , FADH , COA )

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10
Q

reaction 1

A

GLUCOSE -P➔ 6phosphogluconolactone

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11
Q

reaction 1 est

A

irreversible

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12
Q

enzyme de la 1e

A

glycose6P deshydrogenase

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13
Q

coenzyme de la 1e

A

NADP+

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14
Q

2e reaction

A

6 phosphogluconolactone+H2O ➔ 6 phosphogluconate + H+

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15
Q

2e reaction est

A

reversible

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16
Q

enzyme de la 2e

A

lactonase

17
Q

reaction 3

A

6 phosphogluconate ➔ ribulose 5p +CO2

18
Q

reaction 3 est

A

irreversible

19
Q

enzyme de la 3e

A

6phosphogluconate deshydrogenase

20
Q

coenzyme de la 3e

A

NADP+

21
Q

reaction 3b

A

ribulose 5p➔ribose5P

22
Q

enzyme de la reaction 3b

A

isomerase

23
Q

reaction 3a

A

ribulose5P ➔xylulose 5P

24
Q

enzyme de la 3a

A

epimerase

25
Q

reaction 4

A

xylulose5p + RIBOSE 5p ➔glyceraldehyde 3P + sedoheptulose 7p

26
Q

enzyme de la reaction 4

A

trancetolase

27
Q

reaction 5

A

glyceraldehyde 3P + sedoheptulose 7p➔ erythrose 4phosphate + fructose 6p

28
Q

enzyme de la reaction 5

A

transaldolase:(-3C) cetose ➔ aldose

29
Q

reaction 6

A

erythrose 4phosphate + xylulose 5 phosphate ➔ glyceraldehyde + fructose 6phosphate

30
Q

enzyme reaction 6

A

transcetolase :(-2C) cetose➔aldose

31
Q

regulation de ppp

A

seule la partie oxydative est regulee

32
Q

enzyme cle de ppp

A

glucose 6P deshydrogenase

33
Q

inhibiteur de lenzyme cle

A

rapport NADPH/NADP+ élevé

34
Q

activateur de l enzyme cle

A

insulin

35
Q

bilan de ppp

A

ne consome pas et ne produit pas d ATP

BIOCHIMIE METABO (6 decks)

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