TCA Flashcards
The TCA cycle provides the most?How many?
Is aerobic or anaerobic?
ATP 24
aerobic
Most of the body’s catabolic pathways converge on?
TCA cycle
TCA produces all the______in body.
CO2
What drives the direction of the cycle?
The concentration of substrates
Tell me the pathway to TCA?
Pyruvate is transported into the mitochondria to be converted into acetyl coa by the pyruvate dehydrogenase complex which produces C02 by removing a carbon from pyruvate and 1 NADH
TCA takes place in the?
mitochondrial matrix
________is the final pathway where oxidative metabolism of carbohydrates, amino acids, and fatty acids converge.
TCA cycle
TCA creates a lot of _____for other processes in cell.
substrates
TCA cycle also provides building blocks for some______and______ _____synthesis.
amino acids
fatty acid synthesis
What shits looks like a “traffic circle”?
TCA cycle
Citrate from TCA cycle exit the cell into the cytosol and participates in?
fatty acid synthesis
Oxaloacetate is important to be used as
common precursor to change other amino acids(pyruvate) back into gluconeogenic pathway
Genetic pyruvate dehydrogenase deficiency
results in congenital lactic acidosis by shunting to lactate pathway
Genetic pyruvate dehydrogenase deficiency S/S
CNS defects and early death
similar to arsenic poisoning
How does pyruvate get into the mitochondria?
goes through the pyruvate dehydrogenase complex,
uses substrate lipoic acid, facilities the mutation of pyruvate to acetyl-CoA
