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Sem 2 year 2 > TBL - Prostaglandins > Flashcards

TBL - Prostaglandins Flashcards

1
Q

What are the three main Pg substrates?

A

AA
DGLA
EPA

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2
Q

What is AA?

A

Arachidonic Acid

Gives rise to 2 series

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3
Q

What is DGLA

A

Dihomogamma-linolenic acid

Gives rise to 1 series

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4
Q

What is EPA?

A

Eicosapentaenoic Acid

Gives rise to 3 series

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5
Q

PG biosynthesis summary

A

arachidonic avid liberated by phospholipase A2
Arachidonate converted to parent PGs by COX 1 or 2
Parent PGs rapidly catalysed to inactive metabolites

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6
Q

Prostaglandins are involved in:

A 
Fever generation
Ovulation,fertilisation, parturition
GI Function
Renal function
Carcinogenesis
Bone remodelling
Sleep
Inflammation and pain
Allergy and immunity
Vascular homeostasis and haemostasis
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7
Q

What frees AA from membranes

A

Phospholipase A2

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8
Q

DP mediates

A

Vasodilation
Inhibits platelet aggregation
GI I relaxation

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9
Q

FP mediates

A

Luteolysis

Bronchoconstriction

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10
Q

IP mediates

A

Vasoconstriction
Inhibits platelet aggregation
Fibrinolysis

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11
Q

TP mediates

A

Vasoconstriction
Platelet aggregation
Bronchoconstriction

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12
Q

EP1 mediates

A

GI contraction

Pyrexia

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13
Q

EP2 mediates

A

Bronchodilation
Vasodilation
Stimulates GI fluid secretion

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14
Q

EP3 mediates

A

GI relaxation
Inhibits gastric acid secretion
Inhibits ANS transmitters
Pyrexia

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15
Q

EP4 mediates

A

Vasodilation
Bone homeostasis
Pyrexia

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16
Q

What is athrotec made up of?

A

Diclofenac+misoprostol

17
Q

What is misoprostol?

A

EP 1/3 agonist
Restores cytoprotection
Prevents stomach ulcers

18
Q

What is E2 responsible for?

A

Inflammation

19
Q

What is D2 responsible for

A

Immunity

20
Q

What is F2 responsible for

A

Vasoconstriction

21
Q

What is PGI2

A

Prostacyclin

A potent vasodilator that inhibits platelet aggregation

22
Q

What is TXA2

A

Thromboxane

Inducer of platelet aggregation

23
Q

What does the COX-1 pathway do?

A

Reduce platelet aggregation
Decrease AA-induced inflammation
Sensitive to radiation injury
Resistant to indomethacin-induce gastric ulceration

24
Q

What does the COX-2 pathways do?

A

Defective ovulation, fertilization, implantation, decidualization
Decreased brain injury induced by ischemia
Suppression of tumourgenesis
Renal nephropathy
Cardiac fibrosis
Peritonitis
Failure of patent ductus arteriosus closure

25
Q

What can prostaglandins on carcinogenisis cause?

A

Apoptosis
Angiogenesis
Proliferation
Migration

Sem 2 year 2 (9 decks)

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