Medicine for TBL

Question 1

Delayed release

Answer 1

Drug released at a later time (ec)

Question 2

Repeat action

Answer 2

Individual dose soon after admin the repeats later on (tab inside tab)

Question 3

Prolonged release

Answer 3

Absorbed over longer period but onset delayed as slower release rate from dosage form

Question 4

Sustained release

Answer 4

Initial release for therapeutic dose then gradual release over extended period

Question 5

Extended release

Answer 5

Release drug slowly- plasma conc maintained for prolonged time

Question 6

Controlled Release

Answer 6

Release drug at constant rate and provide plama concs that remain invarient with time

Question 7

Which formulations leave stomach rapidly?

Answer 7

Solution and pellets <2mm

Question 8

Which formulations can stay in the stomach for up to 10 hours if taken with a heavy meal?

Answer 8

single dose units >7mm

Question 9

How long is the transit time through the small intestine?

Answer 9

3 hours

Question 10

How do wax matrix systems work?

Answer 10

Drug in a hydrophobic matrix - remain intact during drug release
Contact with aq media, channeling agent dissolves and leaches out leaving porous matrix of tortuous capillaries
Drug dissolves and diffuses out of the system via capillaries
Rate of release governed by diss and diff of CA and drug

Question 11

How do hydrophilic matrix systems function?

Answer 11

Colloids swell in contact with water = hydrated matrix layer which controls further diffusion into the matrix and the diffusion through the hydrated matrix layer controls the rate of release of the drug
Outer hydrated matrix layer erodes as it becomes more diluted - rate of erosion depends on nature of the colloid

Question 12

Osmotic pump delivery

Answer 12

Drug in tablet core which is soluble and solubilizes drug in presence of water
core coated with a semi perm membrane which allows water topass into core
Core dissolves - hydrostatic pressure builds up which forces drug solution through hole in coating

Question 13

MST Continus tablets

Answer 13

API in hydrated hydroxyalkyl cellulose and a higher aliphatic alcohol

Question 14

MST Continus suspension granules

Answer 14

CATIONIC exchange resin (drug positive)

Morphone displaced by potassium and sodium ions

Question 15

Zomorph

Answer 15

Pellets in capsule shell

Ethyl cellulose coating - diffuse throyugh this

Question 16

MXL capsules

Answer 16

Hard gelatin caps with multiparticulates

Capsule disintegrates, water enters multiparticulates, morphine diffuses out

Question 17

Ideal for TD patch

Answer 17

Polar 
unionized
form H bonds
Low MR 
Amphiphillic