TBL Objectives Flashcards
Exclusion criteria for Beurec et al.
HIV positive
Inclusion criteria for Beurec et at.
Age
How do you distinguish E. coli strains?
PCR
Shigella and Salmonella agar
Hektoen Agar
Assay for viral detection
immunoassays
Detection of helminth?
Stool sample looking for EGGs
Detection of protozoa?
Stool sample looking for CYSTS
Toxin of rotavirus?
NSP4 toxin
What does secretor status mean?
Actie fucosyltransferase 2 gene
So you CAN make 2-fucosylated glycans
Helps bifido grow
Bimodal distribution of bifido?
Production of lactate and short chain fatty acids (SCFA) and the influence on pH. Once a certain threshold of bifidobacteria is reached, the amount of SCFA and lactate produced alter the pH of gut lumen → overcomes buffering capacity of luminal contents → lower pH → shifts bacterial community structure as the non-acid-tolerant members of community die off
Factors contributing to higher prevalence of liver disease in AI/AN populations
Predominately male
Hx of IV drug use
Midlife years
Connection to urban centers
How is hep C transmitted?
Exposure to infected blood
Detection of Hep C?
Serologic test of antibody to HCV (anti-HCV)
+
Molecular assay for HCV RNA
MOA of interferon alpha
anti viral protein normally synthesized by viral infected cells
SE of interferon alpha
Myopathy
Neutropenia
MOA of Ribavirin
inhibits inosine monophosphate dehydrogenase
Blocks synthesis of gaunine nucleotides
SE of Ribavirin
Hemolytic anemia
Teratogen
MOA Simeprevir
Inhibits viral NS3/4A protease
SE of Simeprevir
Photosensitivity
Rash
Sofosbuvir
Inhibits viral NS5B polymerase
SE of Sofosbuvir
Fatigue
Headache
Nausea
Daclatasvir
Ledipasvir
Inhibits NS5A = phosphoprotein involved in setting up RNA replication factory
