TB treatment Flashcards

1
Q

How do you manage latent TB?

A

If worried about hepatotoxicity:
- 3 months of isoniazid (with pyridoxine) and rifampicin

If worried about interactions with rifampicin (HIV and transplant patients):
- 6 months isoniazid (with pyridoxine)

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2
Q

How do you manage active TB?

A
RIPE
- R - Rifampicin 450mg (<50kg), 600mg (≥50kg) 
      6 months
- I - Isoniazid 300mg
      6 months
- P - Pyrazinamide 1.5g (<50kg), 2g (≥50kg) 
      2 months 
- E - Ethambutol 15mg/kg 
      2 months
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3
Q

What are the side effects of rifampicin?

A
  • Red/orange coloured body fluids
  • Hepatits
  • Skin reactions
  • Flu syndrome
  • GI symptoms
  • Thrombocytopenia
  • Reduced effect of drugs metabolised by cytochrome P450 enzymes (OCP)
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4
Q

What are the side effects of isoniazid?

A
  • Hepatitis
  • Skin reactions
  • Peripheral neuropathy
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5
Q

What are the side effects of pyrazinamide?

A
  • Hepatitis
  • Flushing
  • GI symptoms
  • Arthralgia
  • Hyperuricaemia (gout)
  • Skin reactions
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6
Q

What are the side effects of ethambutol?

A
  • Retrobulbar neuritis
    Can result in blindness -> stop treatment
    Eye-thambutol
  • Arthralgia
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7
Q

What do you need to give with isoniazid?

A

Pyridoxine (vitamin B6) for peripheral neuropathy

- Im-so-numb-azid

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8
Q

How long do you continue treatment for if there are meningeal/CNS symptoms?

A

10 months

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9
Q

How long do patients need to isolate for before they are established onto treatment?

A
  • 2 weeks
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