TB and HIV

Question 1

‘more’ essential T cells in TB infection

Answer 1

CD4s- mice without these die quicker

Question 2

why is the efficacy of antibodies in TB questioned

Answer 2

is an intracellular bacterium so shouldnt do anything

Question 3

immune evasion of TB

Answer 3

‘decoy’ antigens which can redirect immune system
evading TLR signalling
manipulation of MHC II antigen presentation
living within APCs, preventing phagocytosis/lysosome function

Question 4

what can kill HIV infected cells

Answer 4

CD8+ cells

Question 5

HIV immune evasion mechanisms

Answer 5

blocking interferon production
downregulating MHC class I expression
adding glycan shields to envelope proteins