TB

Question 1

TB:

causative organism

Answer 1

Mycobacterium tuberculosis

Question 2

TB:

MoT

Answer 2

vehicle (airborne)

Question 3

TB:

Virulence factors (2)

Answer 3

lipids in wall, ability to stimulate strong CMI

Question 4

TB:

Culture/ Dx (5)

Answer 4

culture, PCR, IGRA, skin test, chest X-ray

Question 5

TB:

Prevention (2)

Answer 5

avoid airborne M. tuberculosis, BCG vaccine in other countries

Question 6

TB:

Treatment (5)

Answer 6

isoniazid, rifampin, pyrazinamide + ethambutol or streptomycin (long lengths of time)

Question 7

TB: drug resistant

Treatment (3)

Answer 7

multi-drug regimen, may include bedaquiline or delamanid SERIOUS THREAT CATEGORY

Question 8

TB:

Symptoms

Answer 8

Primary- tubercules (can become necrotic and caseous, then calcified)
Secondary- violent coughing, greenish or bloody sputum, low-grade fever, anorexia, weight loss, fatigue, night sweats, chest pain
Extrapulmonary/ disseminated- affects regional lymph nodes, intestines, kidneys, long bones, genital tract, brain or meninges