Targets for CNS Drugs

Question 1

Ketamine:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 1

Glutamate
NMDA receptor non-competitive antagonist
Anesthetic or pain
Drug of abuse

Question 2

Phencyclidine:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 2

Glutamate
NMDA receptor non-competitive antagonist
Drug of abuse

Question 3

Diazepam:
What is the affected signaling system?
What is the drug target or mechanism?
What are properties of the drug?
What is the drug used for?

Answer 3

GABA
Wide range GABA-A receptor modulator
Anxiolytic, anticonvulsant, sedative, hypnotic, muscle relaxant, amnesic
Anxiety, epilepsy, anticonvulsant, agitation, insomnia, muscle spasms, pre-anesthesia

Question 4

Midazolam:
What is the affected signaling system?
What is the drug target or mechanism?
What are properties of the drug?
What is the drug used for?

Answer 4

GABA
Wide range GABA-A receptor modulator
Anxiolytic, anticonvulsant, sedative, hypnotic, muscle relaxant, amnesic
Anxiety, epilepsy, anticonvulsant, agitation, insomnia, muscle spasms, pre-anesthesia

Question 5

Zolpidem:
What is the affected signaling system?
What is the drug target or mechanism?
What are properties of the drug?
What is the drug used for?

Answer 5

GABA
Narrow range GABA-A receptor modulator
Sedative, hyponotic
Insomnia

Question 6

Eszoplicone:
What is the affected signaling system?
What is the drug target or mechanism?
What are properties of the drug?
What is the drug used for?

Answer 6

GABA
Narrow range GABA-A receptor modulator
Sedative, hyponotic
Insomnia

Question 7

Baclofen:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 7

GABA
GABA-B receptor agonist
Spasticity

Question 8

L-DOPA:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 8

Dopamine
Substrate for dopamine synthesis
Parkinson’s

Question 9

Amphetamine:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 9

Dopamine
Increase vesicular dopamine release
ADD
Drug of abuse

Question 10

Haloperidol:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 10

Dopamine
D2 receptor competitive antagonist
Antipsychotic for schizophrenia

Question 11

Cocaine:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 11

Dopamine
Dopamine reuptake inhibitor
Drug of abuse

Question 12

Fluoxetine:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 12

Serotonin
Serotonin reuptake inhibitor (SSRI)
Depression, OCD, bulemia, panic disorders

Question 13

Clonidine:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 13

Norepinephrine
Alpha-2 adrenoreceptor agonist
Opiate withdrawal

Question 14

Nicotine:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 14

Acetylcholine
NAChR agonist
Being a fuckhead

Question 15

Carbamazepine:
What is the affected signaling system?
What is the drug target or mechanism?
What is the drug used for?

Answer 15

Voltage-gated ion channels
Use-dependent voltage gated sodium channel blocker
Anticonvulsant