memory

Question 1

Long term potentiation

Answer 1

long lasting enhancement of synaptic transmission resulting from high-frequency stimulation of presynaptic cell paired with depolarization of post-synaptic cell

occurs at Glu synapses in HIPPOCAMPUS

@ Rest:

• MDA and AMPA binds Glu
• Mg2+ blocks NMDA receptor, AMPA mediates

Post-Synaptic Depolarization
1) EPSP summmation leads to prolonged depolarization
2) Mg2+ expelled from NDMA channel
3) Ca2+ enters postysynaptic neuron
4) protein kinases activated– substrate phosphorylation
more AMPA receptors inserted that are sensitive to Glu
more glutamate released

Question 2

Where are memories stored?

Answer 2

CORTEX!

Question 3

Where are new memories stored?

Answer 3

Hippocampus

Question 4

Wernickes Encephalopathy or Korsakoff syndrome

Answer 4

prolonged B1 (thamine) deficiency!

affects mammillary bodies, DM nucleus of thalamus, cerebellar vermis, CN II, IV, VI and VIII

Question 5

where is working memory? Executive Functions (problem solving)?

Answer 5

Prefrontal cortex

limited in capacity and storage duration