Targeted therapy Flashcards
What are the two types of molecule seen in targeted therapy
small molecules
large molecules
what are small molecules referred to as
tyrosine kinase inhibitors
what are large molecules referred to as
monoclonal antibodies
what is the suffix of a tyrosine kinase inhibitor
nib
how are small molecule drugs delivered vs large molecule drugs
oral for small
parenteral for big
How do small molecules exert an affect
they affect the intracellular mechanisms
how do large molecules cause an effect
they target extracellular targets and enable a change within the cell
what is the primary intra cellular target of small molecules
protein kinase
what does protein kinase do
when it is dysregualted leading to an increase in proliferative signalling
how to protein kinase inhibitors work
they inhibit the phosphorylation of proteins that are involve in cellular signal transduction pathways
what is the most common small molecule drug
imatinib
what is a monoclonal antibody
they are a type of y shaped antibody that are man made and are involved in eliminating pathogens.
what are the different sources that monoclonal antibodies produce copies from in the lab.
animals
mice
humanized
human
what are the two ways in which monoclonals work
direct and indirect mechanism
outline the two direct mechanisms of monoclonal antibodies
monoclonal antibodies bind with a target receptor and block the signals needed for growth
monoclonal antibodies combine with other cytotoxic agents and facilitate the direct delivery of a toxic substance to the cell
