Targeted Chemo/Biologic agents

Question 1

What tyrosine kinases are inhibited by Imatinib? What cancers can it be used for?

Answer 1

BCR-ABL, C-Kit

CML and GIST

Question 2

What growth factor receptor TKI should be used for HER2+ breast cancer? What antibody can be used?

Answer 2

Lapatinib- TKI

Trastuzumab- Antibody

Question 3

What is Dasatinib used for?

Answer 3

In Imatinib-resistant CML and Ph+ ALL

Question 4

What gene mutation is treated with Vemurafenib and what is the common cancer associated?

Answer 4

For BRAF V600E mutations

Metastatic melanoma

Question 5

What tyrosine kinases does Sorafenib target and what cancer is it typically used for?

Answer 5

Targets PDGFR and VEGFR, also Raf

Use for RCC

Question 6

What antibody is effective against the VEGF ligand? What cancer is it used for?

Answer 6

Bevacizumab

Used for RCC- or added to chemo to prevent solid tumor angiogenesis

Question 7

What are the EGFR receptor antibodies? What cancer are they used against?

Answer 7

Cetuximab and Panitumumab

Wild-type colorectal cancer (without KRAS mutations)

Question 8

What mutation can cause treatment resistance in EGFR antibody inhibition?

Answer 8

KRAS- Allows bypass of EGFR inhibition

Question 9

What is Rituximab used for?

Answer 9

NHL, CLL, autoimmune Dz

CD20+ B cell Lymphoma

Question 10

What are the aromatase inhibitors and what patients are they used for?

Answer 10

Anastrazole and Exemestane (inactivator)

Used for estrogen receptor+ breast cancer in post-menopausal women

Question 11

What are the RTK inhibitors that target EGFR?

Answer 11

Erlotinib and Gefitinib

Question 12

What RTK oncogenes do GIST’s usually contain and what is used to treat them?

Answer 12

c-KIT or PDGFRa

Imitanib to treat or Sunitinab if imitinab-resistant

Question 13

Tamoxifen causes an increased risk of what cancer?

Answer 13

Endometrial (partial ER agonist in endometrium)