Management of Chemo Sx Flashcards
What can be used to prevent Cisplatin nephrotoxicity?
Amifostine (Pro-Drug activated by Alk Phos)
What can be given to blunt cardiotoxicity of Doxorubicin?
Dexrasoxane
What is the toxic metabolite of Cyclophosphamide and how can its toxicity be diminished?
Acrolein
MENSA can be given to prevent hemorrhagic cystitis
After HDMTX treatment, what toxicity can be “rescued” and by what drug?
The HDMTX toxicity of myelosupression can be rescued in normal cells by Leucovorin
What should be given for anticipatory CINV?
Benzodiazapines (Diazapam/Lorazepam, etc.)
What drug combo should be given to a patient with a highly emetogenic chemo regimen?
A 5HT antagonist (-setron), Aprepitant (NK1 receptor antagonist), and a corticosteroid
What chemo drug is most likely to cause delayed emesis and what can be given to treat it?
High-dose cisplatin most commonly causes delayed emesis- treat with NK1 antagonist (Aprepitant)
5-HT3 Receptor antagonists can be given for what type of CINV and what is the most significant adverse effect?
Given for acute CINV
What is the ABVD regimen used for and what are the drugs used in it?
Used for Hodgkins Lymphoma
A- Adriamycin (Doxorubicin), B-Bleomycin, V-Vinblastine, D-Dacarbazine
What is the CHOP regimen used for and what drugs does it contain?
Used to treat NHL
C-Cyclophosphamide, H-Hydroxydaunorubicin, (doxorubicin), O-Oncovin (Vincristine), P-Prednisone
What is the toxicity of Prednisone?
Hyperglycemia and Osteopenia
What is the toxicity of Vincristine?
Neuropathy and constipation
What is the toxicity of Doxorubicin (Hydroxydaunorubicin)?
Cardiotoxicity (Dilated cardiomyopathy, CHF)
What cell cycle phase does cyclophosphamide act on?
Trick question- Cell cycle non-specific (alkylating agent)
