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SBL > Chemo- Anti-Mitotic Drugs/Topoisomerase Inhibitors > Flashcards

Chemo- Anti-Mitotic Drugs/Topoisomerase Inhibitors Flashcards

1
Q

What is the MOA of Vinca alkaloids?

A

Bind to B tubulin and inhibit polymerization

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2
Q

What is the MOA of Taxanes?

A

Enhance tubule polymerization and stabilize microtubules

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3
Q

What cell-cycle phase do Vinca alkaloids and Taxanes act on?

A

M phase (impair spindle integrity)

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4
Q

What are the taxanes and what cancers are they used for?

A

Paclitaxel and Docetaxel- Used for solid tumors- especially advanced breast and ovarian cancer

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5
Q

What is the therapeutic use of Vincristine?

A

WALEN: Wilm’s tumor, ALL, lymphoma, Ewings sarcoma, Neuroblastoma

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6
Q

What is Vinblastine used for?

A

Testicular cancer (wi/bleomycin and cisplatin), lymphomas, neuroblastoma

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7
Q

What is Vinorelbine used for?

A

Advanced non-small cell lung cancer

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8
Q

What are the side effects of Vincristine?

A

Neurotoxicity and peripheral neuropathy!!

Also blisters and paralytic ileus

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9
Q

What are the side effects of Vinblastine and Vinorelbine?

A

Bone marrow suppression and blisters (vesicant)

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10
Q

What are the side effects of Paclitaxel?

A

Severe hypersensitivity during infusion!

Also neutropenia, thrombocytopenia, peripheral neuropathy

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11
Q

What can cause treatment failure for the Vinca allaloids and taxanes?

A

P-glycoprotein expression by tumor cells–> pumps drug out of cells and can cause relapse of cancer

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12
Q

What are the Epipodophyllotoxins and what is their MOA?

A

Etoposide and Teniposide

Inhibit Topoisomerase 2–> cause dsDNA breaks

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13
Q

What are the Camptothecins and what is their MOA?

A

Irinotecan and Topotecan

Inhibit Topoisomerase 1–> cause ssDNA breaks

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14
Q

What is Etoposide used for?

A

Oat cell carcinoma of the lung and testicular cancer; (wi/cisplatin and bleomycin)

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15
Q

What is Teniposide used for?

A

Glioma and Neuroblastoma

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16
Q

What is Irinotecan used for?

A

Metastatic colon cancer

17
Q

What is Topotecan used for?

A

Second-line treatment for various cancers that failed prior 1st line treatment

18
Q

What is the Dose limiting toxicity of Irinotecan?

A

Severe diarrhea! And myelosupression

19
Q

What is the dose limiting toxicity of Etoposide?

A

Leukopenia, and secondary cancer (leukemia)

20
Q

What is the MOA of topoisomerase inhibitors?

A

Bind to DNA-enzyme complex and create a persistently cleavable complex

21
Q

What are the differences in the cell cycle activity of topoisomerase 1 and 2 inhibitors?

A

Topoisomerase 1 inhibitors- S phase

Topoisomerase 2 inhibitors- CCNS

SBL (6 decks)

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