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Pharmacotherapy 7 > Targeted Cancer Agents > Flashcards

Targeted Cancer Agents Flashcards

1
Q

Tamoxifen

Toremifene

A

SERM (antiestrogen)
Toxicity: fatigue, hot flashes, mood swings, vaginal discharge, fluid retention, nausea, thromboembolic events, endometrial hyperplasia

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2
Q

Fulvestrant

A

SERD (antiestrogen)
Toxicity: fatigue, hot flashes, mood swings, vaginal discharge, fluid retention, nausea, thromboembolic events, endometrial hyperplasia

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3
Q

Exemestane
Letrozole
Anastrozole

A

Aromatase Inhibitor
Block production of estrogen
Toxicity: fatigue, hot flashes, nausea, hypercholesterolemia, arthralgias, bone fractures, weight gain

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4
Q

Bicalutamide

Enzalutamide

A

Antiandrogen
Block 5 alpha reductase
Toxicity: hot flashes, N/V, LFT abnormalities, gynecomastia, gal actor Rhea, interstitial pneumonitis, edema, HTN, HA

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5
Q

Abiraterone

A

Antiandrgen
Block testosterone production by binding CYP17
Toxicity: edema, joint swelling, hypokalemia, hot flashes, HTN, increased urinary frequency, URI, LFT abnormalities, lab abnormalities

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6
Q

Lauprolide
Goserelin
Triptorelin

A

LHRH agonist
Activates pathway because negative feedback loop which eventually causes the pathway to shut down
Toxicity: hot flashes, decreased libido, impotence, gynecomastia, tumor flare

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7
Q

Abarelix

A

GnRH antagonist
Directly block production of LH and FSH
Toxicity: life threatening allergic reactions, hot flashes, breast enlargement/pain, tiredness

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8
Q

Degarelix

A

GnRH antagonist
Directly block production of LH and FSH
Toxicity: Injection site reactions, hot flashes, weight increase, increases in transaminases

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9
Q

Bevacizumab

A

VEGF inhibitor (antibody)
Binds to circulating VEGF, prevents ligand from binding to receptor
Toxicity: Infusion related reaction, bleeding, thromboembolism, proteinuria, HTN, GI perforation, Reversible posterior leukoencephalopathy syndrome (RPLS), nephrotoxic

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10
Q

Ziv-aflibercept

A

VEGF inhibitor (antibody)
VEGF-trap, recombinant fusion protein
Toxicity: infusion related reaction, bleeding, thromboembolism, proteinuria, HTN, GI perforation, RPLS, myelosuppression, elevated LFTs, dysphonia, diarrhea

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11
Q

Ramucirumab

A 
VEGF inhibitor (antibody)
VEGFR2 antagonist (binds to receptor)
Toxicity: infusion related reaction, bleeding, thromboembolism, proteinuria, HTN, GI perforation, RPLS
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12
Q

Sunitinib

A 
VEGF inhibitor (small molecule)
Multiple Tyrosine Kinase inhibitor
Toxicity: Diarrhea, rash, hand-foot reaction, HTN, bleeding, skin/hair discoloration, CHF, QT prolongation, hypothyroidism, hepatotoxicity
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13
Q

Regorafenib

A

VEGF inhibitor (small molecule)
MTKI
Toxicity: Fatigue/asthenia, decreased appetite, hand-foot syndrome, diarrhea, mucositis, HTN, dysphonia, hepatotoxicity, hemorrhage

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14
Q

Sorafenib

A 
VEGF inhibitor (small molecule)
MTKI
Toxicity: rash, hand-foot syndrome, diarrhea, HTN, QT prolongation, drug induced hepatitis, hypophosphatemia
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15
Q

Cetuximab

Panitumumab

A

EGFR inhibitor (antibody)
EGFR 1 antibody
Toxicity: infusion related reaction, acneform rash, malaise, diarrhea, electrolyte wasting (Mg), pulmonary toxicity

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16
Q

Necitumumab

A

EGFR inhibitor
EGFR 1 antibody
Toxicity: infusion related reaction, acneform rash, malaise, diarrhea, electrolyte wasting (Mg), pulmonary toxicity, thromboembolic events

17
Q

Erlotinib

A

EGFR inhibitor (small molecule)
EGFR TKI
Toxicity: Diarrhea, acneform rash, anorexia, fatigue, N/V, elevated LFTs, pulmonary toxicity

18
Q

Afatinib

A

EGFR inhibitor (small molecule)
EGFR TKI
Toxicity: diarrhea, acneform rash, paronychia, conjunctivitis, anorexia, stomatitis, elevated LFTs, pulmonary toxicity

19
Q

Osimertinib

A 
EGFR inhibitor (small molecule)
EGFR
Toxicity: diarrhea, rash/dry skin, nail toxicity, QTc prolongation, cardiomyopathy, pulmonary toxicity
20
Q

Lapatinib

A 
EGFR inhibitor (small molecule)
EGFR and HER2 TKI
Toxicity: rash, fatigue, diarrhea, left ventricular dysfunction, fatigue, hepatotoxicity, N/V, QT prolongation, pulmonary toxicity
21
Q

Trastuzumab

A

HER2 antibody

Toxicity: infusion related reaction, N/V, myelosuppression, left ventricular dysfunction

22
Q

Pertuzumab

A

HER2 antibody

Toxicity: infusion related reaction, N/V, myelosuppression, left ventricular dysfunction, brith defects//fetal death

23
Q

Ado-Trastuzumab

A

HER2 antibody
Antibody drug conjugate
Toxicity: peripheral neuropathy, diarrhea, infusion related reaction, N/V, elevated LFTs, myelosuppression, left ventricular dysfunction, dyspnea

24
Q

Rituximab

A 
CD20 antibody (B cells)
Toxicity: infusion related reaction, TLS, myelosuppression, viral reactivation, progressive multifocal leukoencephalopathy, severe mucocutaneous syndromes
25
Q

Crizotinib

A

ALK TKI

Toxicity: pneumonitis, hepatotoxicity, QT prolongation, vision disorders, N/V, diarrhea/constipation, edema

26
Q

Ceritinib

A

ALK TKI

Toxicity: ILD, hepatotoxicity, QT prolongation, hyperglycemia, fatigue, N/V, diarrhea/constipation, bradycardia

27
Q

Alectinib

A

ALK TKI

Toxicity: fatigue, constipation, edema, myalgia, elevated CPK, hepatotoxicity, bradycardia, pneumonitis/ILD

28
Q

Vemurafenib

A

BRAF TKI
Toxicity: squamous cell carcinomas, rash, arthralgia, alopecia, photosensitivity, nausea, pruritus, QT prolongation, hepatotoxicity, ocular toxicity

29
Q

Dabrafenib

A

BRAF TKI

Toxicity: Squamous cell carcinomas, rash, arthralgia, alopecia, hyperglycemia, hypophosphatemia, HA, fever

30
Q

Trametinib

A

MEK TKI

Toxicity: rash, diarrhea, stomatitis, elevated LFTs, HTN, hemorrhage, anemia, lymphedema

31
Q

Cobimetinib

A

MEK TKI
Toxicity: Squamous cell carcinomas, rash, diarrhea, elevated LFTs, hemorrhage, photosensitivity, fever, ocular toxicity, cardiomyopathy, rhabdomyolysis, hypophosphatemia

32
Q

Palbociclib

A

CDK inhibitor
Block cells from moving through cell cycle
Toxicity: myelosuppression, N/V, diarrhea, stomatitis, fatigue, URI, neuropathy, alopecia

33
Q

Idelalisib

A

PI3 kinase inhibitor
Targets apoptosis pathway so that tumor cell will die
Toxicity: rash, fever, diarrhea, cough, pneumonia, fatigue, elevated LFTs, hyperglycemia, hypertriglyceridemia

34
Q

Everlimus

Temsirolimus

A

mTOR inhibitors
Stop cell growth and division
Toxicity: BBW, dyslipidemia, thrombocytopenia, hyperkalemia, mucositis

35
Q 
Imatinib
Dasatinib
Nilotinib
Bosutinib
Ponatinib
A

Bcr-Abl inhibitor (TKI)

Toxicity: N/V, diarrhea, muscle cramps, fluid retention, myelosuppression, hepatotoxicity, electrolyte abnormalities, QT

36
Q

Bismodegib

Sonidegib

A

Hedgehog inhibitors

Metastatic Basal Cell carcinoma

37
Q

Ipilumumab

A

CTLA-4 antibody
Toxicity: Hypophysitis, Thyroiditis, Adrenal insufficiency, Enterocolitis, Dermatitis, Pneumonitis, Hepatitis, Pancreatitis, Motor and sensory neuropathies, Arthritis

38
Q

Pembrolizumab
Nivolumab
Atezolizumab

A

PD-1 antibody
Toxicity: Hypophysitis, Thyroiditis, Adrenal insufficiency, Enterocolitis, Dermatitis, Pneumonitis, Hepatitis, Pancreatitis, Motor and sensory neuropathies, Arthritis

Pharmacotherapy 7 (7 decks)

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