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Pharmacotherapy 7 > Drug Doses/PK > Flashcards

Drug Doses/PK Flashcards

1
Q

Tamoxifen

Antiestrogen SERM

A 
20mg po daily
Half-life 7-14 d
Metabolism Hepatic
Excretion Fecal
Substrate of CYP3A4, 2C9, 2D6
P-gp inhibitor
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2
Q

Enzalutamide

Antiandrogen

A 
160mg po daily
Half-life 6-8 days
Wafarin
Substrate 2C8, A4
Inducer 3A4, 2C9, 2C19
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3
Q

Abiraterone

Antiandrogen

A 
1000 mg po daily + Prednisone 5 mg BID
Half life 12H
Metabolism Hepatic
Excretion Fecal
3A4 inhibitors and inducers
Inhibitor 2D6, 2C8
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4
Q

Leuprolide

LHRH agonist

A

3.75 mg IM Qmonth to 22.5 mg IM Q3 months
Half life 3-5H
Metabolism Hydrolysis of C terminal amino acids
Excretion renal
No DDI

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5
Q

Bevacizumab

VEGF inhibitor

A

IV administered over 90 min on an every 2-3 week schedule
Half life 20 days
No DDI

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6
Q

Cetuximab

EGFR inhibitor

A

LD: 400 mg/m2 IV ovre 90 min
MD: 250 mg/m2 IV QW
Premedicate with benadryl
Half life 5 days

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7
Q

Erlotinib

EGFR inhibitor

A 
150 mg po daily (with food)
Half life 24-36H
Metabolism hepatic
Excretion fecal
CYP inducer/inhibitors
Warfarin
Gastric pH altering med
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8
Q

Lapatinib

EGFR inhibitor

A

1250 mg po daily
Half life 24H
Metabolism Hepatic
CYP inducers/inhibitors

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9
Q

Trastuzumab

HER 2 antibody

A

LD: 8 mg/kg IV over 90 min
MD: 6 mg/kg IV Q3W
Half life 6-16 days

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10
Q

Crizotinib

ALK TKI

A 
250mg po BID
Half life 42H (reduced with high fat meal)
Metabolism hepatic
Excretion fecal/urine
CYP inducers/inhibitors
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11
Q

Vemurafenib

BRAF TKI

A 
960 mg po BID
Half life 57H
Metabolism hepatic 
Excretion fecal
CYP inducers/inhibitors
Inhibitor of 1A2, 2D6, P-gp
Induces 3A4
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12
Q

Dabarafenib

BRAF TKI

A 
150 mg po BID
Half life 8H/10-21H (high fat meal)
Metabolism hepatic
Excretion fecal/urine
CYP inducers/inhibitors
Induces 2B6, 2C19, 2C9, 3A4
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13
Q

Trametinib

MEK TKI

A 
2 mg po daily
Half life 4-5 days
Metabolsim deacetylation/glucuronidation
Excretion fecal/urine
Inhibits 2C8
Induces 3A4
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14
Q

Cobimetinib

MEK TKI

A 
60 mg po daily for 21 days of 28 day cycle
Half life 44H
Metabolism Hepatic
Excretion fecal
Inducer/inhibitors 3A4
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15
Q

Palbociclib

CDK inhibitor

A 
125 mg po daily for 21 days with 7 days off
Half life 29H (take with food)
Metabolism hepatic
Excretion fecal/urine
CYP inducers/inhibitors
CYP substrate
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16
Q

Ipilumumab

CTLA-4 antibody

A

3 mg/kg IV over 90 min Q3W (4 doses)

Half life 15 days

17
Q

Pembrolizumab

PD-1 antibody

A

2 mg/kg IV over 30 min Q3W

Half life 26 days

18
Q

Nivolumab

PD-1 antibody

A

3 mg/kg Iv over 60 min Q2W

Half life 26 days

19
Q

Atezolizumab

PD-1 antibody

A

1200 mg IV Q3W

Half life 27 days

Pharmacotherapy 7 (7 decks)

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