Taking and Recording a Family History Flashcards
1
Q
How many generations should be recorded?
A
3
2
Q
What does penetrance mean?
A
probability that a carrier will show features of the condition, the proportion of heterozygotes for a dominant gene who express a trait, even mildly
3
Q
What is expressivity?
A
variation in severity of phenotype
4
Q
What is Mitochondrial inheritance?
A
Only get from mothers egg cell. All offspring of an affected/Carrier are at risk of being affected. All females are at risk of transmitting
5
Q
In what ways should you be sensitive when taking a family history?
A
Non-paternity: genetic implications. Consanguinity. Carefully worded questions: are they full brothers and sisters. Incomplete info: adoption, miscarriage, suicide
