TAG metabolism diseases

Question 1

What is tetrahydrolipstatin?

Answer 1

derived from bacteria; not an appetite suppressant; does not need to be absorbed (is not absorbed); panreatic lipase inhibitor; –reduces calorie intake; not super good at reducing weight–>only a 5-15% decrease is weight

Question 2

side effects of orlistat

Answer 2

steatorrhea

Question 3

side effects of olestra

Answer 3

cramps, gas,bloating, diarrhea, binds to fat-soluble vitamins–>need to supplement

Question 4

what is an advantage of olestra?

Answer 4

cause a large reduction in polychlorinated biphenyls

Question 5

what is MGAT and where is it found?

Answer 5

monoacylglycerol acyltransferase; found only in the intestine, needed for absorption of dietary TAGs

Question 6

waht happens in MGAT2 -/- mice?

Answer 6

have a reduced RATE of dietary fat absorption; no intestinal issues (fatty stools, diarrhea, etc); protects against obesity

Question 7

frederickson classification of type I familial hyperchylomicronemia defect, lipoprot increase, plasma appearance, prevalence

Answer 7

defect in LPL/apoc2, CMs increased, creamy top layer, 1/1 000 000

Question 8

frederickson classification of type II familial hypercholesterolnemia defect, lipoprot increase, plasma appearance, prevalence

Answer 8

defect in LDL receptor, LDL increased, clear, 1/500–uptake problem

Question 9

frederickson classification of type III familial dysbetalipoproteinemia defect, lipoprot increase, plasma appearance, prevalence

Answer 9

defect in apoE, intermediate density lipoprotein increased, clear, 1/10 000

Question 10

frederickson classification of type IV familial hypertriglyceridemia defect, lipoprot increase, plasma appearance, prevalence

Answer 10

increased VLDL, turbid, 1/100–caused by defects in the liver

Question 11

what is ApoC2?

Answer 11

activator of LPL, lipoprotein lipase (expressed on CMs)