Diseases of Lipid Metabolism Flashcards
where is phosphatidylcholine most present?
endoplasmic reticulum
where is sphingomyelin most present?
plasma membrane
where is phosphatidylethanolamine most present?
inner membrane of the mitochondria (lots in outer too)
both phosphatidylserine and phosphatidylinositol are involved in signalling–not abundant in any membranes
ya
where is cardiolipin present?
inner membrane of mito
no phosphatidylcholine in bacteria
ya
what transports TAGs?
chylomicrons and VLDL
what transports cholesterol?
LDL and HDL
as size of the four lipoproteins increases, density decreases
ya
since the lipoproteins have differing densities, they can be separated via centrifugation
ya
Apoprotiens are inexchangeable– once they’re bound to a lipo, they’re bound for good
ya
what lipoproteins is apoB found on?
CM, VLDL, and LDL
where is apoB100 produced and where is it recognized?
produced only in the liver; recognized by LDL receptor in liver and other tissues
what is apoB48, where is it found?
an RNA-edited version of apoB48– 48% similar to apoB100–>editing happens in the intestine; found on chylomicrons
lipid asymmetry exists to help the curvature of the membrane
ya
