Tablets Flashcards
1
Q
Describe the plasma concentration over time graph ?
A
- Y-axis is plasma concentration
- X is time
- T max = time of maximum concentration
- C max = max conc of drug
2
Q
what is the therapeutic window ?
A
- from Cmax to minimum effective concentration
3
Q
what are advantages of taking tablets ?
A
- convenient
- longer shelf life than liquid
- cheap
- precise dosing
4
Q
what are the different types of tablets ?
A
- buccal
- effervescent
- dispersible
- disintergrating
- modified release
- sublingual
5
Q
what kind of release do disintegrating tablets give ?
A
- immediate release
- eg. gastro-resistant tablets
6
Q
what are the 3 types of modified release tablets ?
A
- prolonged = slowly at constant rate
- delayed = released after some time
- pulsatile = drug is released in 2 or more pulses
7
Q
what are dispersible tablets ?
A
- disintegrate in water before administration
8
Q
what are effervescent tablets ?
A
- uncoated tablets, dissolved in water before administration
- bubble
- faster drug absorption
9
Q
what are sublingual and buccal tablets ?
A
- sublingual = under tounge
- buccal = buccal cavity = side of cheek
10
Q
what are lozenges ?
A
- hard, solid
- dissolve in mouth slowly when sucked
11
Q
what are the 3 main stages in tablet formation ?
A
- die filling
- tablet formation
- tablet ejection
12
Q
what is die filling ?
A
- powder flows down from a hopper into the die
13
Q
what happens during tablet formation ?
A
- upper punch comes down
- compresses powder into tablets
- upper punch moves up after compression
14
Q
what happens during tablet ejection ?
A
- lower punch rises to eject tablet
15
Q
what are the 6 tablet excipients ?
A
- Filler
- anti-adherent
- glidant
- disintegrant
- binder
- lubricant
