Capsules Flashcards
1
Q
What are advantages of capsules?
A
- Easy to swallow
- higher drug loading compared to tablets (90%)
- masks smell and taste of drugs
2
Q
What are disadvantages of capsules?
A
- Not suitable for highly soluble or deliquescent materials
- costs more than tablets
3
Q
What are the two types of capsules?
A
- hard capsules ( 2 piece)
- soft capsules (1 piece)
4
Q
Raw materials for capsules ?
A
- gelatin (major component
- water
- plasticisers
- colourants
5
Q
what are properties and problems of gelatin ?
A
- non toxic and non - irritant
- gelatin allergy
- not for vegetarian + religious regions
6
Q
what are hard gelatin capsules ?
A
- more common
- 2 parts = body and a cap which fit together
7
Q
How are hard gelatin capsules manufactured ?
A
- dipping metal molds into a gelatin solution, spinning and drying.
8
Q
What are hard capsule fillings ?
A
- powders (dry)
- pellets (dry)
- granules (dry)
- pastes (semi-solids)
- non-aqueous liquids
9
Q
Examples of excipients used in powder filled capsules ?
A
- diluents - bulk forming properties
- lubricants - reduce powder to metal adhesion
- wetting agents - improve water penetration
- stabilisers - improve stability
- disentegrants
- Glidants - reduce powder cohesion
10
Q
How are hard capsules filled ?
A
- 2 halves are separated
- exact dose placed on body and spread
- cap is locked onto body
11
Q
what are soft capsules (soft-gels) ?
A
- one-piece flexible shell containing liquid or semisolid matrix
12
Q
what are advantages of soft capsules ?
A
- improved drug absorption
- enhanced safety
- better dose uniformity
13
Q
what are the types of softgels ?
A
- oral (cod liver oil)
- chewable
- twist off
- suckable + meltable
14
Q
what are the types of soft-gel matrices ?
A
- lipophilic liquids
- hydrophilic liquids
- self-emulsifying systems
15
Q
manufacture of soft gels ?
A
- single step process
