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S1 Pharmaceutics > BP Testing > Flashcards

BP Testing Flashcards

1
Q

Physical tests for tablets ?

A
  • hardness
  • friabilility
  • general appearance
  • disintegration
  • uniformity of mass
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2
Q

Chemical tests for tablets?

A
  • uniformity of content
  • dissolution (rate drug dissolves)
  • assay of active ingredients (exact quantity of active substances)
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3
Q

physical tests for capsules ?

A

-appearance
- disintegration
- uniformity of mass

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4
Q

chemical tests for capsules ?

A
  • uniformity of content
  • dissolution
  • assay of active ingredients
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5
Q

what are common tablet defects ?

A
  • capping = segments separate horizontally
  • lamination = separates into layers
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6
Q

what are common capsule defects and a cause ?

A
  • cracking
  • pinhole
    cause can be overfilling
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7
Q

what is friability of a tablet ?

A

% weight loss of powder from tablet surface due to mechanical action

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8
Q

procedure of friability test for uncoated tablets ?

A
  • weigh tablet + place in drum
  • rotate drum 100 times
  • remove tablet
  • wipe of any dust
  • weigh
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9
Q

what is a remedy for friability ?

A
  • stronger/ more binder
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10
Q

what is uniformity of weight ?

A
  • weight consistency across tablets
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11
Q

procedure for testing uniformity of weight ?

A
  • weigh 20 tablets individually
  • calculate average mass
  • pass if ‘ no more than 2 individual masses deviate from average by more than certain % and none deviates by double the %
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12
Q

How do tablets/capsules pass uniformity of weight test ?

A
  • no more than 2 masses deviate from average by more than certain % and none deviates by double the %
  • % found in BP
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13
Q

procedure testing for uniformity of weight in capsules ?

A
  • weigh 20 capsules
  • open capsule and empty contents
  • for soft shell wash shell with solvent
  • weigh empty shell
  • mass = weight of filled - empty
  • calculate average
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14
Q

procedure for testing uniformity of weight in powders ?

A
  • remove label + wash + dry outside of container
  • open container and weigh
  • empty container and rinse with water then alcohol and dry
  • weigh empty container
  • calculate mass of contents
  • repeat for all 20
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15
Q

what is uniformity of content ?

A
  • checks active ingredient constant in each form
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16
Q

what is disintegration of a drug ?

A
  • breakdown of a tablet or capsule into smaller fragments
17
Q

what is dissolution of a drug ?

A
  • drug dissolves in the fluids of the gastrointestinal tract
18
Q

what are some factor affecting disintegration of a drug ?

A
  • temperature
  • type and conc of binder used
  • diluent used
19
Q

disintegration test for tablets and capsules ?

A
  • 6 test tubes in rack submerged in water
  • place tablets + capsules in tube
  • disintegrated when no tablet is there
20
Q

what are factors affecting dissolution ?

A
  • solubility
  • pH
  • temperature

S1 Pharmaceutics (7 decks)

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