Tablet

Question 1

Tablets properties

Answer 1

1) have exact dosage of active principles
2) confer maximum stability possible
3) contain only inert additives/excipients
4) aesthetically pleasing
5) suitable for its intended purpose

Question 2

Tablet advantage

Answer 2

1) convenient means of administering
2) delivery an accurate dose
3) small and compact
4) stable product
5) easy to handle and pack
6) high production throughput possible

Question 3

Tablet disadvantage

Answer 3

1) poor compressibility
2) poor wetting
3) slow dissolution
4) high dose
5) bitter taste / bad odour
6) sensitivity to mositure

Question 4

improve tableting output

Answer 4

1) increase the effective number of punches per station by multi-tip punches
2) increase rate of compression (turrent speed)

3) number of points of compression
4) increase number of stations, segmented die.

Question 5

segregation increases when ________

Answer 5

there is a large difference in form, size, and or density of the particles.

Question 6

ensure powder flowability

Answer 6

to ensure

• tablet weight uniformity
• tablet with consistent and reproducible properties.

Question 7

Mechanism strength of tablets depend on

Answer 7

1) Particle size, distribution and shape
(small size = UP SA = more bonding = more strength)

2) granule porosity (no pore = high strength; initial more pore => after compression = higher strength)
3) Moisture content (dry = less strength)

4) Fragmentation and visco-elastic deformation
5) applied load (compaction force)
6) time of loading (strain rate sensitivity)
7) time of unloading (strain rate sensitivity)
8) elastic stress release upon ejection

Question 8

Excipients affecting compaction properties

Answer 8

1) diluent/filler
2) binder/adhesives
3) lubricants, glidants, antii-adherent.

Question 9

Excipients affecting bioavailability, stability, marketing

Answer 9

1) lubricant
2) disintegrant
3) colorant, flavours, sweeteners.

Question 10

Diluent/fillers

Answer 10

Sugars
starch
celluose
inorganic salt

Question 11

binder

Answer 11

cellulose
modified celulose (HPMC etc)
synthetic polymer (PVP etc)
Gums

Question 12

mechanism of disintegration

Answer 12

swelling
wicking
straining recovery
interruption of particle particle bonds
heat of interaction

Question 13

glidant

Answer 13

silicates
fused silica (cab-o-sil,aerosil, syloid)
starch
talc
Mgst, carbonate, oxide
Cast
Znst

Question 14

Disintegrants

Answer 14

Starch
Cellulose
gum
synthetic polymer

Question 15

lubricants

Answer 15

hydrodynamic (fluid type)
- mineral oil / paraffin

boundary (solid) type
- water insoluble
MgSt, CaSt, stearic acid, waxes amd hydrogenated oil

• water soluble
  PEG, Na benzoate, Na acetate, leucine, SDS

Question 16

antiadherent

Answer 16

silicates
starch
talc
Mg,Ca,Zn  stearates 
leucine
SDS