multiparticulate dosage form

Question 1

adv of spheroids as multi-unit dosage form in terms of therapeutics

Answer 1

1) minimize local irritation
2) maximize absorption / bioavailable
3) less susceptable to dose dumping
4) reduction in gastric emptying rates

Question 2

adv of spheroids as multi-unit dosage form in terms of technological

Answer 2

1) superiority of coating
2) uniformity in packing
3) spherical in shape
4) good flow ability
5) low friability

Question 3

extrusion-spheronization steps

Answer 3

1) dry blending
2) wet massing
3) extrusion
4) spheronization
5) drying

Question 4

vegetarian capsule

Answer 4

HPMC
pullulan
carrageenan
alginate

Question 5

tests for hard gelatin capsule

Answer 5

Assay
uniformity of dosage unit
dissolution
disintegration

Question 6

adv for soft gelatin capsules

Answer 6

1) no compression stage, can contain poorly compressible drug
2) liquid fill avoids powder flow and mixing problems
3) avoid oxygen or moisture degradation of drug during long-term storage, protected by gelatin shell
4) for poorly water-soluble drugs, in a liquid vehicle, emulsified in GIT as fine droplets

Question 7

fill material to avoid in soft capsule

Answer 7

1) emulsion
2) surfactant (affect gelating integrity)
3) pH <2.5 hydrolysis of gelatin
4) pH >7.5 tanning effect on gelatin, insolubility
5) aldehydes, cross-linking tanning effect

Question 8

adv of controlled release system

Answer 8

1) extended daytime and night time activity of the drug
2) potential for reduced incidence of side effect
3) reduced dosage frequency
4) increased patient compliance
5) potential lower daily cost to patient (fewer dosage units used)

Question 9

types of CDDS

Answer 9

1) matrix system (like layer)
2) coated system
- coated pellet

Question 10

coating processes

Answer 10

1) compression
2) pan coating
3) air suspension (pellet; 2 methods, solution or suspensation (liquid layering))

4) spray coating
5) melt coating

Question 11

preparaton for ion exchange mechanism of controlled drug release

Answer 11

1) resin and drug in solution
2) filter
3) wash
4) dry
5) formulate and tablet

Question 12

problem for ionexchange drug

Answer 12

1) drug release depend only on ionic environment at absorption site and not on pH, enzyme content
- variability in GIT ionic content (varies with diet and water)

• limitation in drug loading (up to 200-300mg max)
• need suitable function groups