Table

Question 1

Low E Drug IV
- Change in Fu

Answer 1

AUCt: Inverse
AUCu: No Change
F: No Change
t1/2: No Change

Vd: Proportional

Question 2

Low E Drug IV
- Change in Clint’

Answer 2

AUCt: Inverse
AUCu: Inverse
F: No Change
t1/2: Inverse

Question 3

Low E Drug IV
- Change in Q

Answer 3

AUCt: No Change
AUCu: No Change
F: No Change
t1/2: No Change

Question 4

High E Drug IV
- Change in Fu

Answer 4

AUCt: No Change
AUCu: Proportional
F: Inverse
t1/2: Proportional

Vd: Proportional

Question 5

High E Drug IV
- Change in Clint’

Answer 5

AUCt: No Change
AUCu: No Change
F: No Change
t1/2: No Change

Question 6

High E Drug IV
- Change in Q

Answer 6

AUCt: Inverse
AUCu: Inverse
F: When Q increases F increases
t1/2: Inverse

Question 7

Low E Drug Oral
- Change in Fu

Answer 7

AUCt: Inverse
AUCu: No Change
F: No Change
t1/2: When fu decreases t1/2 increases

Vd: Proportional

Question 8

Low E Drug Oral
- Change in Clint’

Answer 8

AUCt: Inverse
AUCu: Inverse
F: No Change
t1/2: Inverse

Question 9

Low E Drug Oral
- Change in Q

Answer 9

AUCt: No Change
AUCu: No Change
F: No Change
t1/2: No Change

Question 10

High E Drug Oral
- Change in Fu

Answer 10

AUCt: Inverse
AUCu: No Change
F: Inverse
t1/2: No Change

Question 11

High E Drug Oral
- Change in Clint’

Answer 11

AUCt: Inverse
AUCu: Inverse
F: Inverse
t1/2: No Change

Question 12

High E Drug Oral
- Change in Q

Answer 12

AUCt: No Change
AUCu: No Change
F: Proportional
t1/2: Inverse