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PHARM 303 > Review > Flashcards

Review Flashcards

1
Q

P-glycoprotein

A

Efflux transporter

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2
Q

ABC

A

Efflux transporter (Active Transport)
- Found on apical membrane
- Found along Brush Border Membrane

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3
Q

SLC

A

Influx transporters (Facilitated Transport)
- Found along basolateral membrane (faces blood)
- Found along Sinusoidal Space

Ex. OAT, GLUT, SGLT2

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4
Q

Transporters
- Highest concentration in liver and kidney

A
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5
Q

Tumour cells have increased P-gp resulting increased efflux of drugs
- Need to inhibit P-gp to have drug effect

A
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6
Q

Total Clearance

A

Renal Liver and Other

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7
Q

Rate of elimination

A

Rate of renal elimination + Rate of liver metabolism + other

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8
Q

Cheapatic

A

Hepatic Clearance

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9
Q

Clint

A

Clearance of both bound and unbound drug

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10
Q

Clint’

A

Clearance of unbound drug

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11
Q

Order of Vd

A

In multi-compartment model

Vbeta > Vss > Vc > Vplasma

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12
Q

What body organ has the highest perfusion rate

A

Kidneys
- Liver, Heart, Brain

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13
Q

What body organ has the lowest perfusion rate

A

Bone, Muscle, Skin

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14
Q

Intrinsic Tissue Permeabulity

A

Dependent on physiochemical properties
- LogP
- Molecular size
- Pka

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15
Q

How to monitor renal clearance

A

Creatinine Clearance

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16
Q

How to monitor hepatic clearance

A

Liver Function Tests

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17
Q

How to know if drug is High E or Low E

A

CLhepatic / Qhepatic

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18
Q

Non-Linear Kinetics
- Vmax

A

Affected by inhibitors and inducers
Non-competitive

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19
Q

Non-Linear Kinetics
- Km

A

Affected by displacement
Competitive

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20
Q

Renal Clearance Table
- Clrenal = Clcr

A

Glomerular Filtration

20
Q

Renal Clearance Table
- Clrenal < Clcr

A

Reabsorption

20
Q

Renal Clearance Table
- Clrenal > Clcr

A

Secretion

21
Q

Low E Drug
- CLh Dependency

A

Clint’

22
Q

High E Drug
- CLh Dependency

A

Q

23
Q

Moderate E Drug
- CLh Dependency

A

Q + Clint’

24
Q

What is Vd beta

A

Represents Elimination + Central + Peripheral + Transfer between Central/Peripheral

25
Q

What is Vd steady state

A

Represents Central + Peripheral + Transfer between Central/Peripheral

26
Q

What is Vc

A

Represents the volume in central compartment

27
Q

What is Vplasma

A

Represents the volume of the plasma

28
Q

Exogenous

A

NSAIDS kick off warfarin

Phenytoin kicks off valproic

29
Q

Endogenous

A

Uremia kicks off phenytoin

30
Q

High Vd drugs favour tissues

A
31
Q

Low Vd drugs favour plasma proteins

A
32
Q

25% of cardiact output is to the kidneys

A
33
Q

Anatomy of Kidney

A

Urine Space
Capillary
Basement Membrane
Mesangium(Smooth muscle contraction of glomerulus)
- Has phagocytes

Bowman’s capsule

Macula Densa

Proximal Tubular

34
Q

Anatomy of Kidney Basement Membrane

A

Slit Diaphragm
Glycosialo Protein Coat
- Keeps charged particles out
Foot Process/podocytes
Solute
Fenestra
- Allows for filtration
Epithelial Cells

35
Q

Capillary in Bowmans Capsule has 3x the pressure of normal capillary

A
36
Q

Normal GFR in healthy patient

A

120-125 mL/min

37
Q

0.9 Fraction Bound
0.1 Fraction Unbound

A
38
Q

Adujusted Body Weight Formula

A

IBW + 0.4 * (ABW - IBW)

39
Q

Drug Drug Interactions

A

Same drug can kick off the same drug
- Probability of interaction is high

40
Q

Ionized vs Uniuonized

A

Ionized drugs are excreted

Unionized drugs are reabsorbed

41
Q

Liver Anatomy

A

Mesenteric Circulation
- Drug goes from gut lumen into the liver

Portal Vein
- Drug that is carried from gut

Hepatic Artery
- Drug that is carreied into the liver from systemic

Hepatic Vein
- Carries drug to rest of the body

Metabolism and Bilary Excretion

42
Q
A

Portal Vein - intro lobules
Hepatic Artery - into lobule
Bile duct - from lobule

Hepatic Vein and Inferior Vena Cava - From liver

43
Q

Sinusoidal Space

Kupffer Cells

Hepatocytes

Space of Disse

Canalicular Space

A
44
Q

Average Q in healthy adult in a 70 kg man

A

1500 mL/min

45
Q

80% of blood is form portal vein
20% is from hepatic artery/

A
46
Q

Zero Order

A

High Dose/Concentration
Always saturated
Not concentration dependent

47
Q

First Order

A

Low Dose/Concentrations
Concentrations are well below saturation
Concentration dependent

PHARM 303 (10 decks)

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