T4L5 - Leukocytes and Inflammation

Question 1

Production of red blood cells

Answer 1

Haemotopoeisis

Question 2

Production of leucocytes

Answer 2

Leucopoeisis

Question 3

Stem cell undergoes

Answer 3

COMMITMENT - increasing specialisation

Decreasing plasticity

Question 4

Leucopoeisis

Answer 4

2 major lineage
Lymphoid - small bland looking
Myeloid - Larger cells, most prominent cytoplasmic granules

Cells may change as they move from blood to tissue or fully mature as effector cells

Question 5

Macrophage

Answer 5

Phagocytosis and activation of bacterial mechanisms

Antigen presentation

Question 6

Dendritic cell

Answer 6

Antigen uptake in peripheral sites

Antigen presentation in lymph nodes

Question 7

Neutrophil

Answer 7

Phagocytosis and activation of bacterial mechanisms

Question 8

Eosinophil

Answer 8

Killing of antibody coated parasites

Question 9

Basophil

Answer 9

Unknown

Question 10

Mast cell

Answer 10

Release of granules containing histamine and other active agents

Question 11

B cells

Answer 11

produce antibodies
○ Antibodies are proteins that bind to antigens
Deal with extracellular infections

Question 12

T cells

Answer 12

○ Precursors produced in bone marrow - complete maturation in thymus during gestation
CD8 T cells are particularly important with intracellular infection (viral)

Question 13

Cytokines

Answer 13

Small proteins released by cells that have an effect on another cell
Interleukin, Tumour necrosis factor alpha or interferon gamma

Question 14

Chemokines

Answer 14

• Small proteins released by cells
• Different protein structure
• Different receptor
• Mainly involved in temporal and spatial organisation
CXCL8 attract neutrophils to site of infection