Drugs

Question 1

Amoxicillin

Answer 1

Aminopenicillin
Good oral bioavailability
Longer half life than penicillin

Question 2

Amoxicillin use

Answer 2

Gram -ve bacteria
S. pyogenes
Pneumococcal infection (resp)
Coliform infections (urinary infection)

Question 3

Amoxicillin mechanism action

Answer 3

Inhibit bacterial cell wall synthesis

Question 4

Amoxicillin adverse reactions

Answer 4

Damage to commensal microflora

Allergy

Question 5

Amoxicillin interactions

Answer 5

Can increase levels of protein bound drugs

Question 6

Clarythromycin

Answer 6

Macrolide
Used for penicillin allergy
s. pyognes infecitions
Coliform

Question 7

Clarythromycin mechanism

Answer 7

Inhibit protein synthesis of bacterial ribosomes (50S)

Question 8

Clarythromycin adverse effect

Answer 8

Nausea and diarrhoea

Alter cardiac conduction

Question 9

Clarythromycin interactions

Answer 9

Inhibit enzymes (cytochrome p450) involved in metabolism of other drugs

Question 10

Vancomycin

Answer 10

Glycopeptide
Only active against Gram +ve bacteria
Active against many resistant strains

Question 11

Vancomycin mechanism

Answer 11

Inhibit bacterial cell wall (peptidoglycan) formation by different target to beta lactams

Question 12

Vancomycin adverse effects

Answer 12

Nephrotoxic

Ototoxic