T3 AQ Flashcards
The morphology of specific muscles within the limb buds is determined by which of the following factors Surrounding CT BMPs Apical ectodermal ridge Noggin
Surrounding connective tissue
Pre muscle cells in the developing limb bud are derived from which of the following sources? Lateral plate mesoderm Somatic dermatomes Somatic myotomes Neural crest
Somatic myotomes
Which of the following represents the principal function of the AER?
Stimulating outgrowth of the limb bud
Setting up the AP axis of the limb bud
Determining the specific characteristic of the ectodermal appendages of the limb
Determining the pattern of neural outgrowth of the lomb
Stimulating outgrowth of the limb bud
If the limb disc of a salamander embryo is rotated 180 degrees, so that both the AP and the DV axes are revered, which of the following would be observed?
The resulting limb would be completely normal with no reversal of axes
The AP axis of the resulting limb would be reversed but not the DV axis
The DV axis of the resulting limb bud would be revered but not the AP axis
Both the AP and the DV axes of the resulting limb would be revered
The AP axis of the resulting limb would be reversed but not the DV axis
Numerous experiments have shown that retinoic acid is capable of inducing the formation of the posterior limb in vertebrates. RA is not the actual morphogen but is capable of activating which of the following genes, which is thought to express the actual morphogen? Shh Wnt-7 Pax-3 Noggin
Shh
Pattern formation along the proximodistal axis of the limb bud is primarily determined by which of the following? Paxa Hoxd Retinoic acid Shh
Hoxd
The presence of webbing between the toes of wading birds such as ducks and the presence of webbed fingers (syndactyly) is most likely associated with which of the following? Overexpression of noggin Oligohydramnios Reduced apoptotic activity Amniocentesis
Reduced apoptotic activity
Which of the following experiments carried out on salamander embryos illustrates that the developing limb is a highly regulative system?
Split a limb primordium in two halves and prevent them from fusing
Juxtapose two equivalent halves of a limb primordium
Remove part of a limb primordium
All of the above
All;
Split a limb primordium in two halves and prevent them from fusing
Juxtapose two equivalent halves of a limb primordium
Remove part of a limb primordium
Which of the following factors functions as the initial initiator of future hindlimb development? Hoxd Tbx4 Shh Gli3
Tbx4
In limb development, the attraction oft he outgrowing nerves to peripheral organs seems to be unspecified to a very high degree. Connections between a nerve and the end organ can be made only if the two correspond to each other. These assumptions are based on which of the following experiments?
An eye was transplanted tot eh side of a salamander embryo after the forelimb rudiment was removed
A salamander forelimb bud was removed and replaced by a hindlimb bud
A salamander limb rudiment was transplanted to the flank (side) of a host salamander
An obstacle (piece of mica) was placed between the spinal cord and the region where the hindlimb rudiment was to develop in a salamander embryo
An eye was transplanted tot eh side of a salamander embryo after the forelimb rudiment was removed
During limb development, pre-muscle cells in the somite express c-met, which is the receptor for which of the following? Pax3 N-cadherin Tcf-4 Scatter factor
Scatter factor
In the formation of limb joints, which of the following signal molecules is responsible for inhibiting BMP in the region of the future joint cavity? Shh Noggin Wnt-1 Eng-1
Noggin
Which of the following occurs when an additional limb bud is transplanted into the immediate vicinity of the host forelimb of a salamander embryo?
Neither limb bud will be supplied by any branches of the brachial plexus
The brachial nerves will develop branches running out to the additional limb and will supply it
The transplanted limb bud will be supplied by local nerves that would normally supply flank muscles
Local brachial plexus nerves deviate from the normal limb bud and supply only the transplanted limb bud.
The brachial nerves will develop branches running out to the additional limb and will supply it
The formation of clubfoot () is associated with which of the following?
A misplaced ZPA
Defective cellular migration from somites
Thalidomide
Oligohydramnios
Neural crest defect
Oligohydramnios
Which of the following is observed when the forelimb rudiment of a salamander embryo is removed so that the limb fails to develop?
The associated spinal ganglia increase to more than 150% of their normal size
Local nerves are not affected
The nerves of the brachial plexus remain smaller (thinner) than they would have been if the limb were still there
Nerves of the future brachial plexus undergo apoptosis
The nerves of the brachial plexus remain smaller (thinner) than they would have been if the limb were still there
Which of the following are NOT derived from neural crest cells? Postganglionic autonomic neurons Autonomic ganglia Sensory neuron cell bodies Motor neuron cell bodies
Motor neuron cell bodies
Trunk neural crest cells utilize three migratory pathways. The earliest (first) emigrating cells following which of the following pathways?
Ventral/sympathoadrenal
Ventrolateral
Dorsolateral
Ventral pathway/Sympathoadrenal pathway
Cranial neural crest cells from region of rhombomeres 6 and 7 are involved in the establishment of which of the following structures? Pharyngeal arch 1 Pharyngeal arch 2 Pharyngeal arch 3 Pharyngeal arch 4
Pharyngeal arch 3
Neural crest cells that give rise to the leaflets of the semilunar valves, thymus, thyroid and parathyroid glands, and the septa that divide the conus arteriosus into the aortic and pulmonary arteries arise from which of the following? Circumpharyngeal Vagus Cardiac Cranial
Cardiac neural crest cells
What neurocristopathies is characterized by pigmentation defects, white stripe in the hair, deafness, and cleft palate among others?
Waardenburg Syndrome
A low concentration of what factors results in placode formation, which a high concentration of the same factor results in the formation of neural plate?
BMP
What factor is referred to as the “master gene of eye development” in Drosophila and in human eye development is necessary to induce the formation of the lens placode?
Pax-6
In the development of the retina, the nasotemporal (anterior-posterior) axis is fixed first (before the dorsoventral axis). This axis is established, in part, by gradients composed of what?
Ephrins
Except for pharyngeal arch musculature, the rest of the pharyngeal arch mesenchyme is derived from what source?
Neural crest
Except for the first pharyngeal pouch, patterning of the pharyngeal arch endoderm is heavily based on exposure to which of the following factors? BMPs Retinoic acid FGF10 Shh
Retinoic acid
Shaping of the snout involves the establishment of a gradient between what pairs of signals?
FGF8 and Shh
What develops from the cartilaginous portion of the second pharyngeal arch?
Stapes
The palate forms during which of the following time periods? 1-3 weeks 4-5 weeks 6-10 weeks 11-15 weeks
6-10 weeks
Cranial neural crest cells from region of rhombomere 4 is involved in the establishment of which of the following structures? Pharyngeal arch 1 Pharyngeal arch 2 Pharyngeal arch 3 Pharyngeal arch 4
Pharyngeal arch 2
Cranial neural crest cells from region of rhombomeres 1 and 2 are involved in the establishment of which of the following structures? Pharyngeal arch 1 Pharyngeal arch 2 Pharyngeal arch 3 Pharyngeal arch 4
Pharyngeal arch 1
Tendons of limb muscles arise from the lateral plate mesoderm. Limb muscles arise from which of the following sources? Dorsal lip of the myotome Ventral buds of myotomes Ventrolateral dermomyotome Paraxial somitomeres
Ventrolateral dermomyotome
The morphology of specific muscles within the limb bud is determined by which of the following factors? Surrounding connective tissue BMPs Apical ectodermal ridge Noggin
Surrounding connective tissue
Pre-muscle cells in the developing limb bud are derived from which of the following sources Lateral plate mesoderm Somitic dermatomes Somitic myotomes Neural crest
Somitic myotomes
Which of the following represents the principle function of the AER?
Stimulating outgrowth of the limb bud
Setting up the AP axis of the limb bud
Determining the specific characteristics of the ectodermal appendages of the limb
Determining the pattern of neural outgrowth of the limb
Stimulating outgrowth of the limb bud
If the limb disc of a salamander embryo is rotated 180 degrees, so that both the AP and the DV axes are reversed, which of the following would be observed?
The resulting limb about be completely normal with no reversal of axes
The AP axis of the resulting limb would be revered but not the DV axis
The DV axis of the resulting limb would be revered but not the AP axis
Both the AP and DV axes of the resulting limb would be reversed
The AP axis of the resulting limb would be reversed but not the DV axis
Numerous experiments have shown that retinoic acid is capable of induing the formation of the posterior limb in vertebrates. Retinoic acid is not the actual morphogen but is capable of activating which of the following genes, which is thought to express the actual morphogen? Sonic Hedgehog Wnt 7 Pax 3 Noggin
Sonic Hedgehog
Pattern formation along the proximodistal axis of the limb bud is primarily determined by which of the following? Pax a Hox d RA Shh
Hoxd gene
The presence of webbing between the toes of wading birds such as ducks and the presence of webbed fingers (syndactyly) is most likely associated with which of the following? Overexpression of Noggin Oligohydramnios Reduced apoptotic activity Amniocentesis
Reduced apoptotic activity
Which of the following experiments carried out on salamander embryos illustrates that the developing limb is a highly regulative system?
Split a limb primordium into two halves and prevent them from fusing
Juxtapose two equivalent halves of a limb primordium
Remove part of a limb primordium
All of the above
All of the above
Which of the following factors functions as the initial initiator of future hindlimb development? Hoxd Tbx4 Shh Gli3
Tbx4
In limb development, the attraction of the outgrowing nerves to peripheral organs seems to be unspecific to a very high degree. Connections between a nerve and the end organ can be made only if the two correspond to each other. These assumptions are based on which of the following experiments?
An eye was transplanted to the side of the salamander embryo after the forelimb rudiment was removed
A salamander forelimb bud was removed and replaced by a hindlimb bud
A salamander limb rudiment was transplanted to the flank (side) of a host salamander
An obstacle (piece if mica) was placed between the spinal cord and the region where the hindlimb rudiment was to develop in a salamander embryo
An eye was transplanted to the side of the salamander embryo after the forelimb rudiment was removed
During limb development, pre-muscle cells in the somite express c-met, which is the receptor for which of the following? Pax 3 N-cadherin Tcf-4 Scatter factor
Scatter factor
In the formation of limb joints, which of the following signal molecules is responsible for inhibiting BMP in the region of the future joint cavity? Shh Noggin Wnt 1 Eng 1
Noggin