T2 - Diabetes (Josh) Flashcards
Where is Proinsuline secreted and strored?
Where is it converted into Insulin?
Pancreas (Islets of Langerhans)
Liver
Pancreatic Cells:
— cells make glucagon
— cells secrete insulin
Alpha
Beta
Glucagon:
What is it used for?
released by pancreatic alpha cells
goes to liver and releases glucose from storage sites in liver
DM:
Why treat Type 1 with insulin?
because they don’t produce insulin
— is the converting of simple substance into more complex compounds
— is breaking them down again to be used for energy
Anabolism
Catabolism
— is the formation of glucose from non-carbohydrate sources (fat, protein)
Gluconeogenesis
***occurs in liver
— is the formation of glycogen from glucose to be stored in liver
Glycogenesis
— is the conversion of glycogen into glucose to be used for energy.
Glycogenolysis
Hyperglycemia:
3 Cardinal Signs
Polyuria
Polydipsia
Polyphagia
Hyperglycemia:
Why would you pee alot?
glucose has a high level of osmolality
***leads to dehydration
Hyperglycemia:
What happens to K+?
levels are all over the map
**constantly monitor potassium
Hyperglycemia:
What does HCT look like?
high
blood is highly concentrated and viscous due to dehydration (polyuria)
Hyperglycemia:
What type of respirations?
Kussmaul Respirations due to acidotic state
DM:
Risk factors
AA, Hispanic, American Indians
BMI over 24
45 years or older
Overweight child
DM:
Which type is an autoimmune disorder?
Type 1
***beta cell destruction leading to absolute insulin deficiency
DM:
Symptoms of Type 1
Abrupt onset
Thirst
Hunger
Weight loss (usually not obese)
Polyuria
DM:
With —, the beta cells are destroyed.
With —, the beta cells are dysfunctional.
Type 1
Type 2
DM:
Symptoms of Type 2
NOT ALWAYS PRESENT
Thirst
Fatigue
Blurred Vision
Vascular or Neural Complications
DM:
Diagnostic criteria for Type 2
A1c = 6.5%
Fasting plasma glucose greater than 126 mg/dL
2 hr Glucose greater than 200
Casual Glucose greater than 200
***must be at least one of these
What is metabolic syndrome?
simultaneous presence of different metabolic factors known to increase risk for developing Type 2 and Cardiovascular Disease
Metabolic Syndrome:
What are teh factors that predispose for developing Type 2?
Abdominal Obesity
Hyperglycemia
HTN
Hyperlipidemia
***need to be all at same time
Metabolic Syndrome:
What Abdominal Obesity measure are we looking for?
Men: waist greater than 40 in
Women: waist greater than 35 in
Metabolic Syndrome:
What Hyperglycemia levels are we looking for?
Fasting BS of 100 mg/dL or greater or on treatment for elevated glucose
Abnormal A1c (between 5.5% and 6.0%)
Metabolic Syndrome:
What HTN levels are we looking out for?
SBP of 130 or greater
DBP of 85 or greater
Or on drug treatment for HTN
Metabolic Syndrome:
What Hyperlipidemia levels are we looking for?
Triglycerides greater than 150
HDL less than 40 for men
HDL less than 50 for women
What needs regular checkups and can be an early sign of microvascular complications from DM?
Eye exams
DM:
What should a DM patient check every day?
Foot care, Foot care, Foot care
***they should look at their feet every day b/c they may feel fewer sensations and may not notice a sore and not care for it properly
DM:
To deal with Diabetic Neuropathy, what should they drink?
Drink 2-3 liters per day
Avoid Soda
Avoid ETOH (excess)
DM:
What meds should be avoided due to kidney probs?
Acetaminophen
NSAIDs
DM:
What is the Dawn Phenomenon?
phenomenon occuring in most people where blood sugar levels increase from about 4am to 8 am (preparing the body to wake up)