T1DM Flashcards
1
Q
What is the pathophysiology of T1DM?
A
Absolute insulin deficiency
Type IV hypersensitivity - autoimmune destruction of Beta cells
- causing hyperglycaemia
2
Q
Which genes predispose to T1DM?
A
HLA - DR3 & 4
3
Q
What are the key presentations typical of T1DM?
A
- WL (lipolysis & proteolysis)
- 3 P’s + glucosuria
- young
4
Q
What is the treatment for T1DM?
A
Insulin Tx
Basal-bonus regimen:
- long-acting overnight
- short-acting before mealtimes
5
Q
What is cited as a common complication of T1DM?
A
Diabetic Ketoacidosis (DKA)
