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PHAR417 > T1-Drugs > Flashcards

T1-Drugs Flashcards

1
Q

Acetylcholine

A

cholinergic agonist- muscarinic miosis(pupil constriction) during surgery

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2
Q

carbachol

A

cholinergic agonist- muscarinicmiosis(pupil constriction) during surgery

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3
Q

bethanechol

A

cholinergic agonist- muscarinic. improve poor bladder tone and increase GI motility

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4
Q

methacholine

A

cholinergic agonist- muscarinic. used for asthma test

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5
Q

pilocarpine

A

cholinergic agonist- muscarinic. reduce IOP in open angle glaucoma

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6
Q

cevimeline

A

cholinergic agonist- muscarinic. dry mouth

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7
Q

chantix

A

cholinergic agonist- nicotinic. stop smoking

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8
Q

atropine

A

selective muscarinic antagonist: mydriases(dilate iris) and thicken lens.

  • decrease mucosal secretion
  • increase BP
  • increase HR
  • overactive bladder
  • muscarinic agent or cholinesterase inhibitor poisoning treatment
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9
Q

hyoscyamine

A

selective muscarinic antagonist

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10
Q

ipratropium

A

selective muscarinic antagonist: bronchodilation in asthma

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11
Q

tiotropium (spiriva)

A

selective muscarinic antagonist:

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12
Q

tolterodine (detrol)

A

selective muscarinic antagonist: urinary urgency

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13
Q

oxybutynin

A

selective muscarinic antagonist: urinary urgency

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14
Q

solifenacin (vesicare)

A

selective muscarinic antagonist: urinary urgency

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15
Q

benztropine (cogentin)

A

selective muscarinic antagonist: parkinsons

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16
Q

scopolamine

A

selective muscarinic antagonist:

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17
Q

glycopyrrolate

A

selective muscarinic antagonist

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18
Q

darifenacin (enablex)

A

selective muscarinic antagonist

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19
Q

cyclopentolate

A

selective muscarinic antagonist

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20
Q

amitriptyline

A

nonselective muscarinic antagonist

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21
Q

dicyclomine

A

nonselective muscarinic antagonist

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22
Q

benadryl

A

nonselective muscarinic antagonist

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23
Q

ambenonium

A

cholinesterase inhibitor

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24
Q

demecarium

A

cholinesterase inhibitor

25
Q

donepezil

A

cholinesterase inhibitor

26
Q

echothiophate

A

irreversible cholinesterase inhibitor. treats glaucoma

27
Q

galantamine

A

cholinesterase inhibitor

28
Q

malathione

A

irreversible cholinesterase inhibitor

29
Q

DFP

A

irreversible cholinesterase inhibitor for glaucoma

30
Q

neostigmine

A

semi reversible cholinesterase inhibitor for glaucoma, and MG therapy

31
Q

physostigmine

A

reversible cholinesterase inhibitor for glaucoma and atropine toxicity

32
Q

pyridostigmine

A

semi reversible cholinesterase inhibitor for MG

33
Q

rivastigmine (exelon)

A

cholinesterase inhibitor

34
Q

tacrine

A

cholinesterase inhibitor

35
Q

edrophonium (tensilon)

A

reversible cholinesterase inhibitor for diagnosing and dose assessment of MG

36
Q

soman

A

irreversible cholinesterase inhibitor

37
Q

tabun

A

irreversible cholinesterase inhibitor

38
Q

pralidoxime (2-PAM)

A

cholinesterase regenerator

39
Q

atracurium

A

non depolarizing nicotinic antagonist

40
Q

doxacurium

A

non depolarizing nicotinic antagonist

41
Q

mivacurium

A

non depolarizing nicotinic antagonist

42
Q

pancuronium

A

non depolarizing nicotinic antagonist

43
Q

rocuronium

A

non depolarizing nicotinic antagonist

44
Q

tubocurarine

A

non depolarizing nicotinic antagonist

45
Q

dantrolene

A

non depolarizing nicotinic antagonist

46
Q

d-tubocurarine

A

non depolarizing nicotinic antagonist

47
Q

vencuronium

A

non depolarizing nicotinic antagonist

48
Q

succinylcholine

A

depolarizing nicotinic antagonist

49
Q

decamethonium

A

depolarizing nicotinic antagonist

50
Q

general receptor effects of cholinergic agonist

A
  • decrease HR and BP
  • increase GI motility
  • pupil constriction
  • increase secretion
  • bronchial constriction
51
Q

general receptor effects muscarinic antagonists :CNS

A

-increase vagal nerve activity

52
Q

general receptor effects muscarinic antagonist: cardio

A
  • decrease HR initially b/c of vagal nerve stimulation. eventually blocking of M2 receptors cause an increase in BP
53
Q

general receptor effects muscarinic antagonist: respiratory

A

-bronchodilation

54
Q

general receptor effects muscarinic antagonist: GI

A
  • decrease in:

salivation, gastric secretion, and GI motility

55
Q

general receptor effects muscarinic antagonist: urinary

A

urine retention (relaxed ureter and bladder smooth muscle)

56
Q

general receptor effects muscarinic antagonist: sweating

A

atropine fever

57
Q

general receptor effects cholinesterase

A
  • decrease HR
  • decrease BP
  • increase Gi motility
  • pupil constriction
  • increase then decrease in IOP
  • increase in secretions
  • bronchial constriction
58
Q

general receptor effects depolarizing nicotinic antagonist

A
  • activation receptors to cause Na influx, causing partial depolarization and contraction.
  • when Ach activates the receptor further, flaccid paralysis can occur
  • the partially depolarized motor end plate results in inactive nicotinic channels and Ach cannot repolarize
59
Q

general receptor effects non depolarizing nicotinic antagonist

A
  • 2 Ach binds to nicotinic receptor to activate. if 1 is antagonist, the activity is decreased
  • can be reversed by cholinesterase inhibitors

PHAR417 (10 decks)

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