T1: Acute Coronary Syndrome (1) Flashcards

1
Q

Acute coronary syndrome (ACS) includes symptoms that occur due to an imbalance of ____ ____ demand and supply.

A

myocardial oxygen

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2
Q

What 2 things cause angina?

A
  • blockage

- spasm

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3
Q

List 3 types of angina:

A

stable angina
unstable angina
variant angina

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4
Q

What occurs when heart muscle tissue is irreversibly damaged?

A

myocardial infarction

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5
Q

Nonmodifiable risk factors for CAD:

A
  • age
  • gender
  • race
  • family history
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6
Q

Modifiable risk factors for CAD:

A
  • SMOKING!!! (#1 risk factor)
  • obesity (#2 risk factor)
  • elevated serum lipids
  • HTN
  • impaired glucose tolerance
  • high fat diet
  • physical inactivity
  • oral contraceptives
  • cocaine use
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7
Q

Additional risk factors for CAD:

A
  • CKD
  • DM
  • Metabolic syndrome
  • Hyperhomocysteinemia
  • Vascular inflammation
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8
Q

What is a normal homocysteine level?

A

5-15 mmol/L

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9
Q

Vascular inflammation is indicated by what test? What is a normal level of that test?

A

C-Reactive Protein

normal:

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10
Q

T/F: Taking B vitamins may lower homocysteine levels in the blood.

A

True

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11
Q

T/F: Total cholesterol levels > 260 mg/dl gives a client 3 x greater risk for CAD.

A

True

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12
Q

Normal total cholesterol:

A

M & F:

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13
Q

Normal HDL:

A

Male: 35-65 mg/dL
Female: 35-80 mg/dL

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14
Q

Normal LDL:

A

M & F:

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15
Q

Normal HDL to LDL ratio:

A

3:1

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16
Q

Normal VLDL:

A

7-32 ng/dL

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17
Q

Normal triglycerides:

A

Male: 40-160 mg/dL
Female: 35-135 mg/dL

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18
Q

Type of plaque with THICK fibrous cap:

A

stable plaque (atherothrombosis)

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19
Q

Type of plaque with large lipid-rich core and only a THIN fibrous cap. Vulnerable to rupture or erosion.

A

unstable plaque

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20
Q

What can happen when an unstable plaque ruptures?

A

Aggregation of platelets can to a thrombotic occlusion

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21
Q

Stable Angina:

Temporary imbalance between what 2 things?

A

cardiac muscle’s demand for O2 & coronary artery’s ability to supply O2

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22
Q

Stable Angina:

Caused by what?

A

blockage of a coronary artery

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23
Q

Stable Angina:

Predictable or unpredictable?

A

Predictable…often induced by exercise and relieved by rest

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24
Q

Stable Angina:

Relieved by how many NTG tablets?

25
Stable Angina: | Result of fixed lesions of ____ or more of artery.
75%
26
Unstable Angina: | Indication of atherosclerotic plaque ____ and possible ____ formation.
instability | thrombus
27
Unstable Angina: | A change in the pattern of ____.
pain
28
Unstable Angina: | More or less intense than stable?
more intense...may wake up from the pain
29
Unstable Angina: | Relieved by how many NTG tablets?
more than 1
30
Unstable Angina: | Emergent or nonemergent?
Emergent!
31
Variant Angina: | AKA _____ angina
Prinzmetal's
32
Variant Angina: | What causes this?
SPASM of a coronary artery
33
Variant Angina: | Associated with what 3 risk factors?
- smoking - alcohol - cocaine
34
Variant Angina: | Can occur at ____ &/or be ____.
rest | cyclic
35
Variant Angina: | Does this always indicate CAD?
No
36
Variant Angina: | How is it diagnosed?
cardiac cath...meds are given to replicate the spasm in a controlled environment
37
What is silent ischemia?
OBJECTIVE data indicating ischemia w/o pain | 1/3 of pts don't have CP
38
What diagnosis is often associated with silent ischemia?
diabetes | autonomic neuropathy
39
What symptoms may women with angina experience?
- unusual fatigue - sleep disturbance - SOB - weakness - cold sweat - lightheadedness - nausea
40
T/F: Mortality rates are higher for men with CAD.
FALSE! Mortality rates are higher for women (38%) than men (25%).
41
What is the #1 killer of women?
Heart disease | kills more women than the next 7 causes combined!
42
African-American women with heart disease have a ____% greater risk for MI & death than white women.
50%
43
How long can cardiac cells withstand ischemia before necrosis?
20 min
44
What results from necrosis of myocardial tissue due to absence of coronary blood flow?
Myocardial infarction (MI) | "Time is muscle."
45
List 3 causes of MI?
1) plaque rupture 2) coronary thrombosis 3) coronary artery spasm longer than 20 min
46
What is the leading cause of death in the US?
MI
47
90% of MI cases are due to _____.
thrombosis
48
3 ways MI's are classified:
- ECG changes produced - DEPTH of the damage - LOCATION of the affected area
49
What are the "3 I's" of an MI?
Ischemia Injury Infarction
50
Ischemia is shown on ECG as:
``` (Remember: ischemia = T wave) - T wave inversion - tall, peaked T wave - ST depression (this is due to tissue repolarization) ```
51
Injury is shown on ECG as:
STEMI | due to decreased blood supply; returns to normal as injury heals
52
Infarction is shown on ECG as:
pathological Q wave | due to scar tissue that can't depolarize; usually remains on ECG for life
53
When you see a pathological Q wave, what should you find out? Why?
If the pt has had a previous MI | the Q wave changes could indicate either an acute or a past MI and look the same
54
2 classifications of MI:
- Non-ST elevation MI (NSTEMI) | - ST elevation MI (STEMI)
55
STEMI or NSTEMI: Infarction not full thickness
NSTEMI
56
STEMI or NSTEMI: Less likely to have Q waves
NSTEMI
57
STEMI or NSTEMI: Aggressively treated
Both!
58
STEMI or NSTEMI: ST elevation allows for early identification
STEMI