T-cells

Question 1

What are the 2 selection stages in the fomration of T-cells?

Answer 1

+ve selection -> -ve selection

Question 2

What is involved in the +ve selection process for T-cell formation?

Answer 2

How the immature cell reacts to MHC

If it does react -> sound ehhh

If it doesn’t react -> bugger off

Question 3

What is involved in the -ve selection process ofr T-cell formation?

Answer 3

How the immature T-cell reacrs to self-antigens

If it does react -> bugger off

It it doesn’t react -> sound ehh

Question 4

What type of T-cell selection process involved how the forming cell reacts to MHC?

Answer 4

+ve selection

Question 5

What type of T-cell selection process involves how the immature cell reacts to self-antigens?

Answer 5

-ve selection

Question 6

What are the 3 main types of Th (helper) cells?

Answer 6

Th1

Th2

Th17

Question 7

What Th cell are responsible for:

A. Intracellular pathogen reaction

B. Extracellular reaction

C. Mucosal barriers maintenance

Answer 7

A. Th1

B. Th2

C. Th17

Question 8

What types of T-cells are intracellular and what types are extracellular?

Answer 8

Intracellular -> Th1

Extracellular -> Th2 & Th17

Question 9

What type of Th cell, if overative, results in…

A. Type 4 hypersensitivty (e.g. MS)

B. Type 1 hypersensitivty (e.g. asthma)

C. Chronic pro-inflammatory state (e.g. RA)

Answer 9

A. Th1

B. Th2

C. Th17

Question 10

What are the 3 types of T-cells and what is their CD number?

Answer 10

Th -> CD4+

Tc -> CD8+

Treg -> CD25+

Question 11

What does CD stand for?

Answer 11

Cluster of differentiation