t cells

Question 1

Cytotoxic T Cells (CTLs) (CD8+) = ?

Answer 1

killer t cells

Question 2

what activates killer T cells?

Answer 2

MHC I

Question 3

CD4+ = ?

Answer 3

helper, and regulatory t cells

Question 4

these are Activated by MHC II on Antigen Presenting Cells

Answer 4

helper T (CD4)

Question 5

What secretes: interleukin 2 (IL-2)•Interferon gamma (IFN-γ)•TNF

Answer 5

helper T (CD4)

Question 6

Secretes IL-10 and TGFβ

Answer 6

regulatory t cells CD4

Question 7

What must the TCR (t cell receptor) recognize for activation?
what must the Co-receptor recognize?

Answer 7

• cognate antigen

- MHC I or II

Question 8

If the TCR sees non-self AND gets co-stimulated, the T cell is:

Answer 8

activated

Question 9

TCR recognizes cognate antigen on MHC with no co-stimulation?

Answer 9

inactivated

Question 10

TCR recognizes MHC plus self peptides?

Answer 10

apoptosis

Question 11

Two types of TCR’s?

Answer 11

αβ-traditional(95%)

γδ-non-traditional

Question 12

whats the name given to the group of signaling proteins

Answer 12

CD3

Question 13

Most non-traditional T cells do not express either:

Answer 13

CD4 or CD8

Question 14

what TCR is most abundant in the intestine uterus and tongue?

Answer 14

non traditional

Question 15

B7 on APC, and CD28 on T cell is for?

Answer 15

co stimulation(activation)

Question 16

TCR (α,β), and Co-Receptors (CD4 or CD8) are for?

Answer 16

recognition(activation)

Question 17

CD3 (γ,δ,εand ζ), and CD28 on T cell are for?

Answer 17

signaling(activation)

Question 18

what type of signal is CD4, what type of signal is CD8?

Answer 18

• help signal

- kill signal

Question 19

receptor molecule on the T cell. When activated, it amplifies the signal and lowers the number of TCR crosslinks needed for activation?

Answer 19

CD28

Question 20

what t cells have many rafts? what have few?

Answer 20

• experienced t-many

- naive-few

Question 21

Remain in blood and lymph (node to node) providing help for B cells and CTLs
Leave the blood and enter battle sites providing help for soldiers on the front line

Answer 21

-roles of helper T cells

Question 22

communication proteins for the immune system and others:

Answer 22

cytokines

Question 23

TNF, IFN-γ, IL-4, IL-5, IL-6, IL-10, IL-17, IL-21 are all:

Answer 23

cytokines

Question 24

senses LPS which is characteristic of Gram-negative bacteria, senses proteins made by certain viruses

Answer 24

TLR4

Question 25

recognizes double-stranded RNA

Answer 25

TLR3

Question 26

identifies proteins specific to Gram-positive bacteria

Answer 26

TLR2

Question 27

Th1 Helper T Cells come in respone to:

Answer 27

viral or bacterial attack

Question 28

Th2 Helper T Cells come in response to:

Answer 28

Parasitic attack or food contaminated with pathogenic bacteria

Question 29

Th17 Helper T Cells come in response to:

Answer 29

Fungal attack and some extracellular bacteria

Question 30

whats the response for intestines under attack?

Answer 30

Th2 Produces IL-4, IL-5, IL-13

Question 31

Dendritic cells make TGFβand IL-6

Enhance neutrophil response Produces IL-17 and IL-21 is the response of what

Answer 31

Th17 helper t cells

Question 32

important for the formation of germinal centers. Once germinal centers are formed, these cells are needed to maintain them and to regulate germinal center B cell differentiation into plasma cells and memory B cells.

Answer 32

TfH follicular helper cells

Question 33

CTL delivers a package with perforin and granzyme B

CTL connects its Fas Ligand to the Fas protein on the target cell
these are:

Answer 33

ways killer t cells kill

Question 34

enzymes and chemicals from the dying cell are released into surrounding tissue. This is extremely damaging

Answer 34

necrosis

Question 35

enzymes and chemicals from the dying cell are neatly contained in vesicles. The vesicles are eaten and disposed of by macrophages

Answer 35

apoptosis