lymphoid organs Flashcards
bone marrow and thymus are?
primary lymphoid organs
Lymph Nodes (500-600 in the body), Spleen, and Mucosal-Associated Lymphoid Tissue are:
secondary lymphoid organs
Where does the recognition phase of the adaptive immune response occur?
secondary lymphoid organs
what is Common within all secondary lymphoid organs?
lymphoid follicles
Loose networks of follicular dendritic cells (FDC), Rich in naïve B cells or memory B cells, “island of FDCs in a sea of B cells”
primary lymphoid follicles
- After antigen stimulation
- Replication and differentiation (germinal center)
secondary lymphoid follicles
Normal function is to catch & display opsonized antigen to B cells with high affinity receptors:
FDC’s
proliferating B cells push aside other B cells and create a : class switching also occurs here:
dark zone
how does the antigen enter the lymph node?
blood or lymph
Lymphocytes leave the blood and enter the lymph node via
also an Entry point for B and T cells to enter secondary lymphoid organs from the blood
High endothelial venules
lined with macrophages, where lymph first enters the node
subscapular sinus
Primary and secondary lymphoid follicles are located here:
cortex
do afferent lymphatics bring lymph to the spleen?
no
where do T cells in the spleen hangout?
periarteriolarlymphocyte sheath (PALS)
where do B cells in the spleen hangout?
area between PALS and marginal sinuses
