restraining immune system Flashcards

1
Q

what restrains the immune system?

A

activated regulatory T cells (Inducible TregsNatural Tregs)

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2
Q

what do regulatory T cells secrete?

A

TGFβ and IL-10

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3
Q

what do activated hyper T cells secrete?

A

TNF and IFN-γ which activate the immune system

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4
Q

Binds to receptors on T cells–Reduces proliferation–Reduces CTL killing

A

TGFβ

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5
Q

Binds to receptors on T cells–Blocks co-stimulatory signals (CD28) –more difficult to activate–Reduces proliferation

A

IL-10

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6
Q

CTLA-4 is binding all the B7 co-stimulatory molecule and…..:

A

blocks co stimulation and activation

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7
Q

B7 binding to naïve T cell’s CD28 causing:

A

co stimulation and activation

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8
Q

major antibody class in intestines & tissues below can bind & neutralize invaders

A

IgA

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9
Q

Develop in MALT, Function to restrain the immune system to keep it from over-reacting to foreign antigen, Function by producing cytokines that suppress the immune response•Two subtypes–Tr1–Th3

A

iTreg(adaptive)

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10
Q

Develop in the thymus•Function to provide protection against T cells with the potential to react against self antigens and cause autoimmune disease that escaped negative selection in the thymus•Thought to require direct cell to cell contactand are antigen specific

A

nTreg

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11
Q

a receptor molecule on the T cell. When activated, it amplifies the signal and lowers the number of TCR crosslinks needed for activation.

A

CD28

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12
Q

receptor molecule on the very experienced T cells. When brought to the membrane, it competes for B7, making co-stimulation and activation more difficult

A

CTLA4

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