T-cell Surface Molecules Flashcards
know the surface molecule, ligand and funcrtion
1
Q
CD4
A
- binds MHC class 2 on APC
2. signal transduction
2
Q
CD8
A
- Binds MHC 1 on APC
2. Signal transduction
3
Q
LFA
A
- binds ICAM on APC, endothelium
2. adhesion of cell
4
Q
CTLA 4
A
- binds CD80 with higher affinity on APC
2. inhibition
5
Q
PD-1
A
- binds PDL1-2 on APC and tumor cells
2. inhibition
6
Q
CD28
A
- Binds CD80 (B7) on APC ‘
2. co-stimulation
7
Q
CD3
A
- no binding
2. signal transduction of TCR
8
Q
Which receptors are present on NAIVE T cells
A
- LFA
- L- selectin
- CCR7
9
Q
T cell activation triggers a cascade producing the following (4)
A
- ^^ CD40 L
- ^^ IL-2
- ^^ CD25 = IL2 receptor
- ^^^ DNA synthesis for T cell cloning
10
Q
What cytokines activate T regulatory cells
A
IL2 and TGF B
11
Q
T regulatory cells express?
What is its transcription Factor?
A
CTLA-4 and CD25
Fox P3
12
Q
What do T regulatory cells secrete?
A
IL10 and TNF B