T-cell Surface Molecules Flashcards

know the surface molecule, ligand and funcrtion

1
Q

CD4

A
  1. binds MHC class 2 on APC

2. signal transduction

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2
Q

CD8

A
  1. Binds MHC 1 on APC

2. Signal transduction

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3
Q

LFA

A
  1. binds ICAM on APC, endothelium

2. adhesion of cell

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4
Q

CTLA 4

A
  1. binds CD80 with higher affinity on APC

2. inhibition

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5
Q

PD-1

A
  1. binds PDL1-2 on APC and tumor cells

2. inhibition

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6
Q

CD28

A
  1. Binds CD80 (B7) on APC ‘

2. co-stimulation

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7
Q

CD3

A
  1. no binding

2. signal transduction of TCR

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8
Q

Which receptors are present on NAIVE T cells

A
  1. LFA
  2. L- selectin
  3. CCR7
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9
Q

T cell activation triggers a cascade producing the following (4)

A
  1. ^^ CD40 L
  2. ^^ IL-2
  3. ^^ CD25 = IL2 receptor
  4. ^^^ DNA synthesis for T cell cloning
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10
Q

What cytokines activate T regulatory cells

A

IL2 and TGF B

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11
Q

T regulatory cells express?

What is its transcription Factor?

A

CTLA-4 and CD25

Fox P3

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12
Q

What do T regulatory cells secrete?

A

IL10 and TNF B

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