T Cell Receptors and MHC

Question 1

Gene responsible for somatic recombination of gene segments that encode antigen receptors:

Answer 1

Recombinase Activating Gene (RAG).

Question 2

Multivalent immune response:

Answer 2

Immune response generated against multiple epitopes.

Question 3

MHC restriction:

Answer 3

T cell receptor binds to both the peptide and the MHC molecule.

Question 4

MHC encodes:

Answer 4

Human Leukocyte Antigens (HLA).

Question 5

MHC is found on chromosome:

Answer 5

Chromosome 6.

Question 6

Antigen presenting genes in class I HLA:

Answer 6

HLA-A, HLA-B, HLA-C

Question 7

Antigen presenting genes in class II HLA:

Answer 7

HLA-DP, HLA-DQ, HLA-DR

Question 8

MHC class I binds peptides from:

Answer 8

Intracellular pathogens and self proteins.

- Presented to CD8 T cell.

Question 9

MCH class II binds peptides from:

Answer 9

Extracellular pathogens.

- Presented to CD4 T cell.

Question 10

Antigen presenting cells express:

Answer 10

MHC class I and II simultaneously.

Question 11

Binding groove of MHC class I:

Answer 11

8-10 aa in length.

Question 12

Binding groove of MHC class II:

Answer 12

8-25 aa in length.

- Bigger, more permissive.

Question 13

Anchor peptides:

Answer 13

Only certain aa residues in the peptide binding groove are critical for a peptide to bind to an HLA molecule.

Question 14

MHC Class I and II proteins can be up-regulated by:

Answer 14

Cytokines INF-gamma and TNF.

Question 15

Antigen processing:

Answer 15

Intracellular degradation of protein antigens into peptides, which are then bound to MHC molecules.

Question 16

Breaks down pathogen proteins for presentation:

Answer 16

Immunoproteasome.

Question 17

Invariant chain:

Answer 17

Blocks binding of peptides to MHC class II molecules in the ER.

Question 18

Facilitates release of CLIP, allowing peptides to bind MHC class II:

Answer 18

HLA-DM

Question 19

B cells present:

Answer 19

Extracellular antigens via HMC class II molecules. 
   - Utilize surface immunoglobulin to capture antigen.