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HDM Cards > T Cell Mediated Immunity > Flashcards

T Cell Mediated Immunity Flashcards

1
Q

IL2 action and source

A

T cell proliferation and Treg cell survival

From activated T cells and APCs

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2
Q

Th1 cell generation

A

IL12 increases STAT4 and Tbet

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3
Q

Th2 generation

A

IL4 increases STAT6 and GATA3 expression

IL4 from Th2 amplifies response

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4
Q

Th17 generation

A

TGFB/IL6/IL1 increases STAT3 and RORyt
IL21 from TF amplifies generation

IL23 from M1 macrophages activates Th17

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5
Q

CD28

A

Main costimulator of Näive T cells

Binds to CD80/CD86 (B7-1/B7-2)

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6
Q

CTLA-4

A

Inhibitory regulation of immune responses, self tolerance

Binds CD80/CD86

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7
Q

PD-1

A

Inhibitory regulation of T cells

Binds PD-L1/PD-L2

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8
Q

ICOS

A

Costimulates effector and Treg cells

Binds ICOSL

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9
Q

Th1 effector action

A

Produce IFNgamma

Activate macrophages and increase IgG production

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10
Q

Th2 effector action

A

Produce IL4, IL5, IL13

Causes IgE isotype switching, recruits mast cells and eosinophils

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11
Q

Th17 effector action

A

Produce IL17A, IL17F, IL22

Recruits neutrophils and monocytes

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12
Q

IFN Gamma actions and sources

A

Activates macrophages

From Tcells and Nk cells

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13
Q

IL4 actions and sources

A

Causes B cell switching to IgE

From mast cells, eosinophils and Th2 cells

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14
Q

IL5 actions and sources

A

Activates eosinophils

From Th2 cells, innate cells and mast cells

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15
Q

IL17 actions and sources

A

Stimulate acute inflammation

Th17 cells

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16
Q

IL22 action and sources

A

Epithelial barrier homeostasis

From Th17 cells, NK cells, Innate lymphoid cells

17
Q

TGF beta action and source

A

Inhibit T cell activation, Treg differentiation

From Treg cells and macrophages

18
Q

IL12 action and source

A

Th1 differentiation, IFN gamma production

From macrophages and dendritic cells

19
Q

Treg generation

A

TGF beta and IL2

IL2 and Retinoic acid (peripheral)

HDM Cards (6 decks)

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